DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: DEG_APCC_DBOX_1

Location: 1168:1176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8875

ASA_SCORE: 101.6778

COIL: 0.816

CONS_SCORE: 0.4642

DSS_SCORE: 0.5477

HELIX: 0.1276

FCONS_SCORE: 1.0509

RIG_SCORE: 0.7316

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1162H	TCGA-BA-A6DA	HNSC	TCGA	ERLELKPID	DEG_APCC_DBOX_1	0.1667
p.D1162H	TCGA-HC-8216	PRAD	TCGA	ERLELKPID	DEG_APCC_DBOX_1	0.1667
p.Q1184K	DO51894	BLCA	ICGC	ERLELKPID	DEG_APCC_DBOX_1	0.1111
p.S1183A	DO8264	COAD	ICGC	ERLELKPID	DEG_APCC_DBOX_1	0.1389
p.R1181H	DO52451	COCA	ICGC	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.P1170S	DO234336	ESAD	ICGC	ERLELKPID	DEG_APCC_DBOX_1	0.6752
p.R1181C	DO41572	UCEC	ICGC	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.R1181C	NB(TU)1-10	autonomic_ganglia	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.K1159R	SIDM00422	Hodgkin's Lymphoma	GDSC	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.K1159R	ACH-001203	Lymphoma	CCLE	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.K1159R	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	0.1944
p.P1178S	CAL-33	upper_aerodigestive_tract	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92859	Neogenin	DEG_APCC_DBOX_1	1168:1176	ERLELKPID	APC,CDC20,FZR1	0.8875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons