Degron: NAPYTPVP
Neogenin
NEO1
842:849
CBL
0.9179
84.675
0.8995
0.2796
0.394
0.0145
0.793
0.7422
Degron related mutations and impact score
| Mutation |
Sample |
Cancer |
Dataset |
Degron |
Degron class |
Impact score |
| p.D837N | TCGA-AR-A0TX | BRCA | TCGA | NAPYTPVP | CBL_PTK | 0.1944 |
| p.D837N | DO1663 | BRCA | ICGC | NAPYTPVP | CBL_PTK | 0.1944 |
| p.P857L | TCGA-EE-A2GI | SKCM | TCGA | NAPYTPVP | CBL_PTK | 0.1111 |
| p.P857L | DO37410 | SKCM | ICGC | NAPYTPVP | CBL_PTK | 0.1111 |
| p.P847L | DO222404 | BTCA | ICGC | NAPYTPVP | CBL_PTK | 0.6471 |
| p.A843S | DO229015 | LICA | ICGC | NAPYTPVP | CBL_PTK | 0.6477 |
| p.P847S | DO220886 | MELA | ICGC | NAPYTPVP | CBL_PTK | 0.5641 |
Drug responses associated with NEO1 mutations
| Sample |
Cancer |
Mutation (In Degron?) |
Dataset |
Drug |
IC50 |
All proteins holding degron of NAPYTPVP
| Uniprot ID |
Source protein |
Degron class |
Location |
Hit |
E3 ligase |
Degron score |
Detail |
| Q92859 | Neogenin | CBL_PTK | 842:849 | NAPYTPVP | CBL | 0.9179 | More... |
