DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: DEG_SIAH_1

Location: 1348:1356

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7472

ASA_SCORE: 95

COIL: 0.9169

CONS_SCORE: 0.3037

DSS_SCORE: 0.6639

HELIX: 0.0328

FCONS_SCORE: 0.7486

RIG_SCORE: 0.605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1345D	TCGA-19-1387	GBM	TCGA	LPTAHVRPS	DEG_SIAH_1	0.25
p.A1363V	TCGA-VQ-A8PT	STAD	TCGA	LPTAHVRPS	DEG_SIAH_1	0.1389
p.T1363S	DO233229	GACA	ICGC	LPTAHVRPS	DEG_SIAH_1	0.1389
p.V1353L	DO229025	LICA	ICGC	LPTAHVRPS	DEG_SIAH_1	0.6765
p.P1357S	DO220899	MELA	ICGC	LPTAHVRPS	DEG_SIAH_1	0.3056
p.P1357S	DO51256	SKCM	ICGC	LPTAHVRPS	DEG_SIAH_1	0.3056
p.P1357L	DO38123	SKCM	ICGC	LPTAHVRPS	DEG_SIAH_1	0.3056
p.P1357L	KYM-1	soft_tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.3056
p.P1357L	CL-34	large_intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.3056
p.A1352V	DO51776	STAD	ICGC	LPTAHVRPS	DEG_SIAH_1	0.6936
p.I1356T	DO51761	STAD	ICGC	LPTAHVRPS	DEG_SIAH_1	0.7078
p.V1364M	SIDM00367	Small Cell Lung Carcinoma	GDSC	LPTAHVRPS	DEG_SIAH_1	0.1111
p.V1364M	SBC-3	lung	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.1111
p.A1363T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LPTAHVRPS	DEG_SIAH_1	0.1389
p.A1363T	ACH-000953	Leukemia	CCLE	LPTAHVRPS	DEG_SIAH_1	0.1389
p.A1363T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.1389
p.T1350I	SIDM00783	Colorectal Carcinoma	GDSC	LPTAHVRPS	DEG_SIAH_1	0.5966
p.T1350I	ACH-000971	Colon/Colorectal Cancer	CCLE	LPTAHVRPS	DEG_SIAH_1	0.5966
p.T1350I	HCT-116	large_intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.5966
p.A1352T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.7139
p.T1339I	HCT-116	large_intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.0833
p.V1353M	SBC-3	lung	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.7208
p.G1353E	COLO-679	skin	COSMIC	LPTAHVRPS	DEG_SIAH_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92859	Neogenin	DEG_SIAH_1	1348:1356	LPTAHVRPS	SIAH1,SIAH2,SIAH3	0.7472	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons