DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: ITCH

Location: 1372:1375

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9601

ASA_SCORE: 95.7

COIL: 0.9338

CONS_SCORE: 0.3702

DSS_SCORE: 0.6014

HELIX: 0.0215

FCONS_SCORE: 0.9144

RIG_SCORE: 0.5937

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1378T	TCGA-A6-6653	COAD	TCGA	PPTY	ITCH	0.25
p.P1369S	DO222737	COCA	ICGC	PPTY	ITCH	0.25
p.P1368L	TCGA-EE-A29D	SKCM	TCGA	PPTY	ITCH	0.2222
p.P1368L	SIDM00945	Colorectal Carcinoma	GDSC	PPTY	ITCH	0.2222
p.P1368L	SIDM00057	Neuroblastoma	GDSC	PPTY	ITCH	0.2222
p.P1368L	SIDM00552	Rhabdomyosarcoma	GDSC	PPTY	ITCH	0.2222
p.P1368L	CL-34	large_intestine	COSMIC	PPTY	ITCH	0.2222
p.P1368L	KYM-1	soft_tissue	COSMIC	PPTY	ITCH	0.2222
p.P1368S	TCGA-GN-A4U4	SKCM	TCGA	PPTY	ITCH	0.2222
p.L1368F	DO229041	LICA	ICGC	PPTY	ITCH	0.2222
p.I1367T	TCGA-VQ-A8P2	STAD	TCGA	PPTY	ITCH	0.1944
p.A1367T	DO10373	COAD	ICGC	PPTY	ITCH	0.1944
p.V1364M	SIDM00367	Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	0.1111
p.V1364M	SBC-3	lung	COSMIC	PPTY	ITCH	0.1111
p.A1363V	TCGA-VQ-A8PT	STAD	TCGA	PPTY	ITCH	0.0833
p.T1363S	DO233229	GACA	ICGC	PPTY	ITCH	0.0833
p.A1363T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPTY	ITCH	0.0833
p.A1363T	ACH-000953	Leukemia	CCLE	PPTY	ITCH	0.0833
p.A1363T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTY	ITCH	0.0833

Showing 1 to 19 of 19 entries

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Drug responses associated with NEO1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPTY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82650	28S ribosomal protein S22, mitochondrial	ITCH	100:103	PPTY	ITCH,NEDD4	0.9899	More...
O14514	Adhesion G protein-coupled receptor B1	ITCH	628:631	PPTY	ITCH,NEDD4	0.9223	More...
Q9UKU9	Angiopoietin-related protein 2	ITCH	227:230	PPTY	ITCH,NEDD4	0.7151	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	1581:1584	PPTY	ITCH,NEDD4	0.9943	More...
Q7Z478	ATP-dependent RNA helicase DHX29	ITCH	459:462	PPTY	ITCH,NEDD4	0.8751	More...
O75175	CCR4-NOT transcription complex subunit 3	ITCH	320:323	PPTY	ITCH,NEDD4	0.7287	More...
O14578	Citron Rho-interacting kinase	ITCH	1926:1929	PPTY	ITCH,NEDD4	0.5412	More...
O75909	Cyclin-K	ITCH	510:513	PPTY	ITCH,NEDD4	0.7979	More...
Q9P2K8	eIF-2-alpha kinase GCN2	ITCH	80:83	PPTY	ITCH,NEDD4	0.7591	More...
Q9H6T0	Epithelial splicing regulatory protein 2	ITCH	584:587	PPTY	ITCH,NEDD4	0.9502	More...
Q9Y6I3	Epsin-1	ITCH	545:548	PPTY	ITCH,NEDD4	0.7626	More...
O14686	Histone-lysine N-methyltransferase 2D	ITCH	2193:2196	PPTY	ITCH,NEDD4	0.9967	More...
Q9BT40	Inositol polyphosphate 5-phosphatase K	ITCH	244:247	PPTY	ITCH,NEDD4	0.9245	More...
P25391	Laminin subunit alpha-1	ITCH	171:174	PPTY	ITCH,NEDD4	0.9366	More...
Q86U70	LIM domain-binding protein 1	ITCH	49:52	PPTY	ITCH,NEDD4	0.9966	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	252:255	PPTY	ITCH,NEDD4	0.9918	More...
Q92859	Neogenin	ITCH	1372:1375	PPTY	ITCH,NEDD4	0.9601	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	ITCH	666:669	PPTY	ITCH,NEDD4	0.8045	More...
P23760	Paired box protein Pax-3	ITCH	450:453	PPTY	ITCH,NEDD4	0.9541	More...
P23759	Paired box protein Pax-7	ITCH	444:447	PPTY	ITCH,NEDD4	0.9893	More...
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ITCH	658:661	PPTY	ITCH,NEDD4	0.6551	More...
Q9UPA5	Protein bassoon	ITCH	1952:1955	PPTY	ITCH,NEDD4	0.8543	More...
A6NMK8	Protein INSYN2B	ITCH	76:79	PPTY	ITCH,NEDD4	0.8124	More...
Q5JSZ5	Protein PRRC2B	ITCH	275:278	PPTY	ITCH,NEDD4	0.8146	More...
Q969W9	Protein TMEPAI	ITCH	229:232	PPTY	ITCH,NEDD4	0.9995	More...

Showing 1 to 25 of 41 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTY

Degron related mutations and impact score

Drug responses associated with NEO1 mutations

All proteins holding degron of PPTY