DegronMD - Q13459(MYO9B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R774C	TCGA-B5-A3FA	UCEC	TCGA	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R774C	DO52402	UCEC	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R761H	TCGA-VQ-A8P2	STAD	TCGA	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8244
p.R761H	DO51761	STAD	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8244
p.I1029M	DO223546	CLLE	ICGC	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.2778
p.R774H	DO8360	COAD	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R774H	SIDM01617	Endometrial Carcinoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R774H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1667
p.R761C	DO222765	COCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.R761C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.R761C	ACH-000938	Leukemia	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.R761C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.8301
p.V2056A	DO222798	COCA	ICGC	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation altering degron motif	0.6936
p.S2141L	DO234287	ESAD	ICGC	PPTY	ITCH	2143:2146	Mutation blocking phosphorylation signal	0.7222
p.V2052I	DO234459	ESAD	ICGC	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation rewiring degron network	0.2222
p.S2152L	DO228948	LICA	ICGC	PPTY	ITCH	2143:2146	Mutation rewiring degron network	0.1667
p.R1030L	DO228981	LICA	ICGC	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.3056
p.S1045I	DO229027	LICA	ICGC	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation blocking phosphorylation signal	0.6667
p.A2151S	DO229006	LICA	ICGC	PPTY	ITCH	2143:2146	Mutation rewiring degron network	0.1944
p.R2139K	DO220878	MELA	ICGC	PPTY	ITCH	2143:2146	Mutation rewiring degron network	0.2222
p.F776L	DO227506	ORCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1111
p.R2046L	DO32893	PACA	ICGC	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation rewiring degron network	0.0556
p.A775T	DO228138	PBCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1389
p.A775T	SIDM00217	Colorectal Carcinoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1389
p.A775T	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1389
p.A775T	SNU-1040	large intestine	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.1389
p.L778M	DO232224	PBCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation rewiring degron network	0.0556
p.P2059S	DO47401	SKCM	ICGC	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation altering degron motif	0.6752
p.P2144T	DO229211	THCA	ICGC	PPTY	ITCH	2143:2146	Mutation altering degron motif	0.7031
p.S1049L	SIDM02026	Colorectal Carcinoma	GDSC	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.1111
p.S766F	SIDM01106	Melanoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.7982
p.S766F	ACH-000822	Skin Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.7982
p.S766F	SK-MEL-24	skin	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	760:768	Mutation altering degron motif	0.7982
p.I1028V	SIDM00498	Colorectal Carcinoma	GDSC	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.25
p.I1028V	ACH-000970	Colon/Colorectal Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.25
p.S2049L	ACH-000107	Pancreatic Cancer	CCLE	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation blocking phosphorylation signal	0.5833
p.S2049L	Capan-2	pancreas	COSMIC	VKTPRRT	DEG_SCF_FBW7_1	2056:2062	Mutation blocking phosphorylation signal	0.5833
p.T2145M	ACH-000304	Skin Cancer	CCLE	PPTY	ITCH	2143:2146	Mutation altering degron motif	0.6312
p.R1036W	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation altering degron motif	0.8634
p.H1023Y	ACH-001960	Bile Duct Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	1031:1041	Mutation rewiring degron network	0.1111

Kaplan plot for MYO9B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO9B

UniProt ID: Q13459

Entrez ID: 4650

Protein name: Unconventional myosin-IXb (Unconventional myosin-9b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO9B in