DegronMD

Uniprot ID: Q13459

Source protein: Unconventional myosin-IXb

Source gene: MYO9B

Class: DEG_APCC_DBOX_1

Location: 760:768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6159

ASA_SCORE: 56.6556

COIL: 0.4256

CONS_SCORE: 0.342

DSS_SCORE: 0.3859

HELIX: 0.4584

FCONS_SCORE: 1.0915

RIG_SCORE: 0.7673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R774C	TCGA-B5-A3FA	UCEC	TCGA	PRSLLQSLS	DEG_APCC_DBOX_1	0.1667
p.R774C	DO52402	UCEC	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1667
p.R761H	TCGA-VQ-A8P2	STAD	TCGA	PRSLLQSLS	DEG_APCC_DBOX_1	0.8244
p.R761H	DO51761	STAD	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.8244
p.R774H	DO8360	COAD	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1667
p.R774H	SIDM01617	Endometrial Carcinoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1667
p.R774H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	0.1667
p.R761C	DO222765	COCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.8301
p.R761C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	0.8301
p.R761C	ACH-000938	Leukemia	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	0.8301
p.R761C	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	0.8301
p.F776L	DO227506	ORCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1111
p.A775T	DO228138	PBCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1389
p.A775T	SIDM00217	Colorectal Carcinoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1389
p.A775T	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	0.1389
p.A775T	SNU-1040	large_intestine	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	0.1389
p.L778M	DO232224	PBCA	ICGC	PRSLLQSLS	DEG_APCC_DBOX_1	0.0556
p.S766F	SIDM01106	Melanoma	GDSC	PRSLLQSLS	DEG_APCC_DBOX_1	0.7982
p.S766F	ACH-000822	Skin Cancer	CCLE	PRSLLQSLS	DEG_APCC_DBOX_1	0.7982
p.S766F	SK-MEL-24	skin	COSMIC	PRSLLQSLS	DEG_APCC_DBOX_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13459	Unconventional myosin-IXb	DEG_APCC_DBOX_1	760:768	PRSLLQSLS	APC,CDC20,FZR1	0.6159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons