DegronMD

Uniprot ID: Q13459

Source protein: Unconventional myosin-IXb

Source gene: MYO9B

Class: DEG_SCF_FBW7_1

Location: 2056:2062

E3 ligase: FBXW7

DEGRON score: 0.9319

ASA_SCORE: 98.2

COIL: 0.8067

CONS_SCORE: 0.3094

DSS_SCORE: 0.555

HELIX: 0.0099

FCONS_SCORE: 0.9283

RIG_SCORE: 0.7275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2056A	DO222798	COCA	ICGC	VKTPRRT	DEG_SCF_FBW7_1	0.6936
p.V2052I	DO234459	ESAD	ICGC	VKTPRRT	DEG_SCF_FBW7_1	0.2222
p.R2046L	DO32893	PACA	ICGC	VKTPRRT	DEG_SCF_FBW7_1	0.0556
p.P2059S	DO47401	SKCM	ICGC	VKTPRRT	DEG_SCF_FBW7_1	0.6752
p.S2049L	ACH-000107	Pancreatic Cancer	CCLE	VKTPRRT	DEG_SCF_FBW7_1	0.5833
p.S2049L	Capan-2	pancreas	COSMIC	VKTPRRT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13459	Unconventional myosin-IXb	DEG_SCF_FBW7_1	2056:2062	VKTPRRT	FBXW7	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons