DegronMD

Uniprot ID: Q13459

Source protein: Unconventional myosin-IXb

Source gene: MYO9B

Class: SCF_FBXL2

Location: 1031:1041

E3 ligase: FBXL2

DEGRON score: 0.9561

ASA_SCORE: 63.4182

COIL: 0.226

CONS_SCORE: 0.5617

DSS_SCORE: 0.2855

HELIX: 0.767

FCONS_SCORE: 1.2518

RIG_SCORE: 0.7677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1029M	DO223546	CLLE	ICGC	LQSLCRGHLQR	SCF_FBXL2	0.2778
p.R1030L	DO228981	LICA	ICGC	LQSLCRGHLQR	SCF_FBXL2	0.3056
p.S1045I	DO229027	LICA	ICGC	LQSLCRGHLQR	SCF_FBXL2	0.6667
p.S1049L	SIDM02026	Colorectal Carcinoma	GDSC	LQSLCRGHLQR	SCF_FBXL2	0.1111
p.I1028V	SIDM00498	Colorectal Carcinoma	GDSC	LQSLCRGHLQR	SCF_FBXL2	0.25
p.I1028V	ACH-000970	Colon/Colorectal Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	0.25
p.R1036W	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	0.8634
p.H1023Y	ACH-001960	Bile Duct Cancer	CCLE	LQSLCRGHLQR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13459	Unconventional myosin-IXb	SCF_FBXL2	1031:1041	LQSLCRGHLQR	FBXL2	0.9561	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons