DegronMD - Q9UJQ4(SALL4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E660D	TCGA-12-3648	GBM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6758
p.E660D	TCGA-BS-A0UV	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6758
p.E660D	DO12604	GBM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6758
p.E660D	DO42793	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6758
p.G843S	TCGA-24-2024	OV	TCGA	PPTY	ITCH	833:836	Mutation rewiring degron network	0.1389
p.G843S	DO32237	OV	ICGC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.1389
p.S824R	TCGA-36-2542	OV	TCGA	PPTY	ITCH	833:836	Mutation blocking phosphorylation signal	0.5278
p.M649I	TCGA-44-7670	LUAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.M649I	DO23555	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.P834L	TCGA-69-7979	LUAD	TCGA	PPTY	ITCH	833:836	Mutation altering degron motif	0.7582
p.T656M	TCGA-93-7348	LUAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.7423
p.T656M	DO25639	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.7423
p.E695A	TCGA-A5-A0G2	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1111
p.E695A	TCGA-A5-A0G2	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.1667
p.E695A	DO41235	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1111
p.E695A	DO41235	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.1667
p.S717L	TCGA-AP-A059	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	TCGA-AP-A059	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.S717L	DO220877	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	DO220877	MELA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.S717L	DO41361	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	DO41361	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.S717L	SIDM00006	Other Solid Cancers	GDSC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	SIDM00006	Other Solid Cancers	GDSC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.S717L	ACH-001552	Skin Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	ACH-001552	Skin Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.S717L	MCC26	skin	COSMIC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1667
p.S717L	MCC26	skin	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.25
p.P833S	TCGA-AX-A0J1	UCEC	TCGA	PPTY	ITCH	833:836	Mutation altering degron motif	0.6752
p.P833S	DO41199	UCEC	ICGC	PPTY	ITCH	833:836	Mutation altering degron motif	0.6752
p.D664Y	TCGA-CA-6717	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.D664Y	DO8264	COAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.R646W	TCGA-D1-A17Q	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.1389
p.R646W	DO227549	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.1389
p.R646W	DO41903	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.1389
p.G723W	TCGA-D3-A2JP	SKCM	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0833
p.G723W	DO47407	SKCM	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0833
p.S705T	TCGA-D3-A3C6	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6005
p.S705T	TCGA-D3-A3C6	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.6005
p.S705T	DO37507	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6005
p.S705T	DO37507	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.6005
p.E694D	TCGA-DF-A2KU	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0833
p.E694D	TCGA-DF-A2KU	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.1389
p.E694D	DO223286	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0833
p.E694D	DO223286	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.1389
p.I715N	TCGA-DI-A1BU	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.2222
p.I715N	TCGA-DI-A1BU	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.3056
p.I715N	TCGA-DI-A1BU	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.0556
p.I715N	DO42023	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.2222
p.I715N	DO42023	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.3056
p.I715N	DO42023	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.0556
p.L712F	TCGA-EA-A43B	CESC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.587
p.L712F	DO44384	CESC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.587
p.P654L	TCGA-EE-A3AB	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6471
p.P654L	DO222670	MELA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6471
p.P654L	DO38057	SKCM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.6471
p.G723E	TCGA-EO-A3B1	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0833
p.G723E	DO52414	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0833
p.P711H	TCGA-FI-A2D5	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7694
p.P711H	TCGA-FI-A2D5	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7694
p.P711H	DO41331	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7694
p.P711H	DO41331	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7694
p.S705F	TCGA-GN-A26C	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	TCGA-GN-A26C	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	TCGA-K4-A5RJ	BLCA	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	TCGA-K4-A5RJ	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	TCGA-YG-AA3N	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	TCGA-YG-AA3N	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	DO49784	BLCA	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	DO49784	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	DO222837	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	DO222837	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	DO37782	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	DO37782	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.S705F	DO51298	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S705F	DO51298	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.7982
p.T710M	TCGA-HU-A4H3	STAD	TCGA	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7423
p.T710M	TCGA-HU-A4H3	STAD	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7423
p.T710M	DO47903	STAD	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.7423
p.T710M	DO47903	STAD	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7423
p.L825V	TCGA-XF-A8HF	BLCA	TCGA	PPTY	ITCH	833:836	Mutation rewiring degron network	0.1111
p.L825V	DO49800	BLCA	ICGC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.1111
p.P713L	TCGA-Z2-A8RT	SKCM	TCGA	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6471
p.P713L	DO218912	SKCA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6471
p.P713L	DO51301	SKCM	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6471
p.T835N	DO234285	ESAD	ICGC	PPTY	ITCH	833:836	Mutation altering degron motif	0.5944
p.T835N	DO234284	ESAD	ICGC	PPTY	ITCH	833:836	Mutation altering degron motif	0.5944
p.M649T	DO233251	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.A832D	DO228985	LICA	ICGC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.3056
p.S698F	DO222908	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1944
p.S698F	DO222908	MELA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0556
p.S698F	DO222908	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.25
p.P702R	DO227929	PBCA	ICGC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation altering degron motif	0.6401
p.G651S	DO232224	PBCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2778
p.H644Y	DO229536	PRAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.0833
p.R646Q	DO42673	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.1389
p.T828M	SIDM01090	Colorectal Carcinoma	GDSC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.1944
p.T721M	SIDM01145	Gastric Carcinoma	GDSC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.0556
p.T721M	SIDM01145	Gastric Carcinoma	GDSC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.1389
p.L712I	SIDM00492	Glioblastoma	GDSC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6063
p.L712I	ACH-000269	Brain Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6063
p.L712I	AM-38	central nervous system	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.6063
p.E840K	SIDM00375	Head and Neck Carcinoma	GDSC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.2222
p.E840K	SKN-3	upper aerodigestive tract	COSMIC	PPTY	ITCH	833:836	Mutation rewiring degron network	0.2222
p.T710S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6005
p.T710S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7116
p.T710S	ACH-000918	Leukemia	CCLE	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6005
p.T710S	ACH-000918	Leukemia	CCLE	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7116
p.T710S	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6005
p.T710S	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation altering degron motif	0.7116
p.S706F	SIDM00901	Endometrial Carcinoma	GDSC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S706F	ACH-000940	Endometrial/Uterine Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.S706F	AN3-CA	endometrium	COSMIC	SSSSKVPTP	DEG_COP1_1	703:711	Mutation altering degron motif	0.6871
p.D692N	SIDM01611	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.0833
p.D692N	ACH-000996	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.0833
p.S698A	ACH-000514	Lung Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	703:711	Mutation rewiring degron network	0.1944
p.S698A	ACH-000514	Lung Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	708:714	Mutation rewiring degron network	0.0556
p.S698A	ACH-000514	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	701:705	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SALL4

UniProt ID: Q9UJQ4

Entrez ID: 57167

Protein name: Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SALL4 in