DegronMD

Uniprot ID: Q9UJQ4

Source protein: Sal-like protein 4

Source gene: SALL4

Class: DEG_COP1_1

Location: 703:711

E3 ligase: COP1

DEGRON score: 0.9961

ASA_SCORE: 71

COIL: 0.773

CONS_SCORE: 0.495

DSS_SCORE: 0.6214

HELIX: 0.0206

FCONS_SCORE: 1.1338

RIG_SCORE: 0.5829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E695A	TCGA-A5-A0G2	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	0.1111
p.E695A	DO41235	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	0.1111
p.S717L	TCGA-AP-A059	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	0.1667
p.S717L	DO220877	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	0.1667
p.S717L	DO41361	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	0.1667
p.S717L	SIDM00006	Other Solid Cancers	GDSC	SSSSKVPTP	DEG_COP1_1	0.1667
p.S717L	ACH-001552	Skin Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	0.1667
p.S717L	MCC26	skin	COSMIC	SSSSKVPTP	DEG_COP1_1	0.1667
p.S705T	TCGA-D3-A3C6	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	0.6005
p.S705T	DO37507	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	0.6005
p.E694D	TCGA-DF-A2KU	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	0.0833
p.E694D	DO223286	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	0.0833
p.I715N	TCGA-DI-A1BU	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	0.2222
p.I715N	DO42023	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	0.2222
p.P711H	TCGA-FI-A2D5	UCEC	TCGA	SSSSKVPTP	DEG_COP1_1	0.7694
p.P711H	DO41331	UCEC	ICGC	SSSSKVPTP	DEG_COP1_1	0.7694
p.S705F	TCGA-GN-A26C	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	TCGA-K4-A5RJ	BLCA	TCGA	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	TCGA-YG-AA3N	SKCM	TCGA	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	DO49784	BLCA	ICGC	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	DO222837	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	DO37782	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	0.6871
p.S705F	DO51298	SKCM	ICGC	SSSSKVPTP	DEG_COP1_1	0.6871
p.T710M	TCGA-HU-A4H3	STAD	TCGA	SSSSKVPTP	DEG_COP1_1	0.7423
p.T710M	DO47903	STAD	ICGC	SSSSKVPTP	DEG_COP1_1	0.7423
p.S698F	DO222908	MELA	ICGC	SSSSKVPTP	DEG_COP1_1	0.1944
p.T721M	SIDM01145	Gastric Carcinoma	GDSC	SSSSKVPTP	DEG_COP1_1	0.0556
p.T710S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SSSSKVPTP	DEG_COP1_1	0.6005
p.T710S	ACH-000918	Leukemia	CCLE	SSSSKVPTP	DEG_COP1_1	0.6005
p.T710S	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSKVPTP	DEG_COP1_1	0.6005
p.S706F	SIDM00901	Endometrial Carcinoma	GDSC	SSSSKVPTP	DEG_COP1_1	0.6871
p.S706F	ACH-000940	Endometrial/Uterine Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	0.6871
p.S706F	AN3-CA	endometrium	COSMIC	SSSSKVPTP	DEG_COP1_1	0.6871
p.S698A	ACH-000514	Lung Cancer	CCLE	SSSSKVPTP	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSSKVPTP

Degron related mutations and impact score

Drug responses associated with SALL4 mutations

All proteins holding degron of SSSSKVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJQ4	Sal-like protein 4	DEG_COP1_1	703:711	SSSSKVPTP	COP1	0.9961	More...