DegronMD

Uniprot ID: Q9UJQ4

Source protein: Sal-like protein 4

Source gene: SALL4

Class: DEG_SCF_FBW7_1

Location: 708:714

E3 ligase: FBXW7

DEGRON score: 0.9753

ASA_SCORE: 70.0143

COIL: 0.8947

CONS_SCORE: 0.4533

DSS_SCORE: 0.5786

HELIX: 0.0114

FCONS_SCORE: 0.9738

RIG_SCORE: 0.6178

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S717L	TCGA-AP-A059	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.S717L	DO220877	MELA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.S717L	DO41361	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.S717L	SIDM00006	Other Solid Cancers	GDSC	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.S717L	ACH-001552	Skin Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.S717L	MCC26	skin	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	0.25
p.G723W	TCGA-D3-A2JP	SKCM	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.0833
p.G723W	DO47407	SKCM	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.0833
p.I715N	TCGA-DI-A1BU	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.3056
p.I715N	DO42023	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.3056
p.L712F	TCGA-EA-A43B	CESC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.587
p.L712F	DO44384	CESC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.587
p.G723E	TCGA-EO-A3B1	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.0833
p.G723E	DO52414	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.0833
p.P711H	TCGA-FI-A2D5	UCEC	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.7694
p.P711H	DO41331	UCEC	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.7694
p.T710M	TCGA-HU-A4H3	STAD	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.7423
p.T710M	DO47903	STAD	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.7423
p.P713L	TCGA-Z2-A8RT	SKCM	TCGA	VPTPLPS	DEG_SCF_FBW7_1	0.6471
p.P713L	DO218912	SKCA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.6471
p.P713L	DO51301	SKCM	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.6471
p.S698F	DO222908	MELA	ICGC	VPTPLPS	DEG_SCF_FBW7_1	0.0556
p.T721M	SIDM01145	Gastric Carcinoma	GDSC	VPTPLPS	DEG_SCF_FBW7_1	0.1389
p.L712I	SIDM00492	Glioblastoma	GDSC	VPTPLPS	DEG_SCF_FBW7_1	0.6063
p.L712I	ACH-000269	Brain Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	0.6063
p.L712I	AM-38	central_nervous_system	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	0.6063
p.T710S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VPTPLPS	DEG_SCF_FBW7_1	0.7116
p.T710S	ACH-000918	Leukemia	CCLE	VPTPLPS	DEG_SCF_FBW7_1	0.7116
p.T710S	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPLPS	DEG_SCF_FBW7_1	0.7116
p.S698A	ACH-000514	Lung Cancer	CCLE	VPTPLPS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTPLPS

Degron related mutations and impact score

Drug responses associated with SALL4 mutations

All proteins holding degron of VPTPLPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJQ4	Sal-like protein 4	DEG_SCF_FBW7_1	708:714	VPTPLPS	FBXW7	0.9753	More...