DegronMD

Uniprot ID: Q9UJQ4

Source protein: Sal-like protein 4

Source gene: SALL4

Class: DEG_SCF_FBW7_2

Location: 653:660

E3 ligase: FBXW7

DEGRON score: 0.9843

ASA_SCORE: 76.05

COIL: 0.9166

CONS_SCORE: 0.5061

DSS_SCORE: 0.5734

HELIX: 0.0224

FCONS_SCORE: 0.8562

RIG_SCORE: 0.6636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E660D	TCGA-12-3648	GBM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.6758
p.E660D	TCGA-BS-A0UV	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.6758
p.E660D	DO12604	GBM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.6758
p.E660D	DO42793	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.6758
p.M649I	TCGA-44-7670	LUAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.M649I	DO23555	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.T656M	TCGA-93-7348	LUAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.7423
p.T656M	DO25639	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.7423
p.D664Y	TCGA-CA-6717	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.D664Y	DO8264	COAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.R646W	TCGA-D1-A17Q	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.R646W	DO227549	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.R646W	DO41903	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.P654L	TCGA-EE-A3AB	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.6471
p.P654L	DO222670	MELA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.6471
p.P654L	DO38057	SKCM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.6471
p.M649T	DO233251	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.G651S	DO232224	PBCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2778
p.H644Y	DO229536	PRAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.0833
p.R646Q	DO42673	UCEC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons