DegronMD - Q9BXA9(SALL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V52M	TCGA-2W-A8YY	CESC	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.0833
p.S72R	TCGA-51-4080	LUSC	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.P91T	TCGA-60-2724	LUSC	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.P91T	DO26540	LUSC	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.E42D	TCGA-77-A5GH	LUSC	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.5647
p.E42D	DO45452	LUSC	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.5647
p.R44C	TCGA-A5-A1OF	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.3056
p.T50A	TCGA-AP-A0LM	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1389
p.T50A	DO43306	UCEC	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1389
p.P772L	TCGA-AP-A1DV	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.6471
p.P772L	TCGA-F4-6570	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.6471
p.E84G	TCGA-AX-A2HJ	UCEC	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.6087
p.E84G	DO42105	UCEC	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.6087
p.A88V	TCGA-AX-A3G9	UCEC	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A88V	DO222467	BTCA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A88V	DO23236	LINC	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A88V	DO46331	OV	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A88V	DO32992	PACA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.A88V	DO41241	UCEC	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.R759H	TCGA-B5-A11E	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.R759H	TCGA-CN-4734	HNSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.G46R	TCGA-BF-A1PX	SKCM	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.25
p.G46R	DO233877	GACA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.25
p.G46R	DO51236	SKCM	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.25
p.L80M	TCGA-BR-8297	STAD	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.5999
p.P770L	TCGA-CA-6718	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.7582
p.P770L	TCGA-EE-A2MS	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.7582
p.R71W	TCGA-CG-4460	STAD	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.R71W	DO38427	STAD	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.T769M	TCGA-CV-5436	HNSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.7423
p.E782K	TCGA-DA-A1HV	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.0833
p.A778V	TCGA-DI-A1BU	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1944
p.E49K	TCGA-EE-A2M5	SKCM	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1667
p.E49K	DO37425	SKCM	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1667
p.M762I	TCGA-EE-A2ME	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.R759S	TCGA-EE-A3AG	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.G763S	TCGA-FR-A726	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.25
p.E84K	TCGA-FS-A1ZZ	SKCM	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.591
p.E84K	DO222402	MELA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.591
p.E84K	DO37412	SKCM	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.591
p.A86V	TCGA-HT-A5RC	LGG	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.A86V	DO48525	LGG	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.A86V	SIDM00216	Colorectal Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.A86V	SIDM01511	Gastric Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.A86V	ACH-000746	Gastric Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.A86V	ACH-000989	Colon/Colorectal Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.P89S	TCGA-L9-A5IP	LUAD	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.P89S	DO49873	LUAD	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.I81M	TCGA-N6-A4VC	UCS	TCGA	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.6507
p.G764R	TCGA-NC-A5HP	LUSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2778
p.E32G	TCGA-PG-A917	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1667
p.E32G	DO52424	UCEC	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1667
p.A762T	DO50575	BOCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.A762T	DO230335	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.A762T	DO233638	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.A762T	DO233624	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.S45I	DO224768	BRCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.2778
p.P91H	DO222990	BTCA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1667
p.R783C	DO222765	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.0556
p.G40R	DO234262	ESAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.7568
p.A34V	DO228732	GACA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.2222
p.R756H	DO233264	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.0556
p.R756H	DO233672	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.0556
p.Q770R	DO15894	HNSC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.7329
p.R94S	DO20808	KIRP	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.A78T	DO50755	LICA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2778
p.P41T	DO45267	LIRI	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.5919
p.D38E	DO25847	LUAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.6758
p.S760C	DO23672	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1667
p.A37S	DO231165	LUSC	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.3056
p.G759S	DO26963	LUSC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.R94H	DO45428	LUSC	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.P78L	DO220891	MELA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2778
p.A37V	DO220906	MELA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.3056
p.P90H	DO46566	OV	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.S777N	DO51515	PACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.2222
p.A29T	DO228138	PBCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.0833
p.R756C	DO48919	PBCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.0556
p.A44V	DO50418	PRAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.3056
p.F94S	DO229453	SKCA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.F94S	ACH-002368	Non-Cancerous	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0833
p.E765K	DO37881	SKCM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.3056
p.S95N	DO229211	THCA	ICGC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.0556
p.Q50R	DO229087	THCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1389
p.R759C	SIDM00944	Colorectal Carcinoma	GDSC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.R759C	ACH-000249	Colon/Colorectal Cancer	CCLE	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.R759C	CL-11	large intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1389
p.G774S	SIDM00545	Melanoma	GDSC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.3056
p.G774S	ACH-000987	Skin Cancer	CCLE	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.3056
p.G774S	Mewo	skin	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.3056
p.G33S	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1944
p.G33S	ACH-000509	Lymphoma	CCLE	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation rewiring degron network	0.1944
p.P90T	SIDM00919	Ovarian Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.P90T	ACH-000713	Ovarian Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.S43N	SIDM00007	Other Solid Cancers	GDSC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.818
p.S43N	ACH-001550	Skin Cancer	CCLE	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.818
p.S43N	MCC13	skin	COSMIC	DSGPES	DEG_SCF_TRCP1_1	38:43	Mutation altering degron motif	0.818
p.V79M	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.V79M	ACH-000481	Lung Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.V79M	NCI-H2170	lung	COSMIC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.P77R	SIDM01140	Ovarian Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.P77R	ACH-001374	Ovarian Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.P77R	PA-1	ovary	COSMIC	LIVHED	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.S769L	HT-115	large intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation altering degron motif	0.7667
p.P761L	OVKATE	ovary	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1944
p.L758R	GP5d	large intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	766:773	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SALL3

UniProt ID: Q9BXA9

Entrez ID: 27164

Protein name: Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SALL3 in