DegronMD

Uniprot ID: Q9BXA9

Source protein: Sal-like protein 3

Source gene: SALL3

Class: DEG_SCF_TRCP1_1

Location: 38:43

E3 ligase: BTRC

DEGRON score: 0.9961

ASA_SCORE: 87.0667

COIL: 0.9287

CONS_SCORE: 0.4559

DSS_SCORE: 0.7853

HELIX: 0.053

FCONS_SCORE: 1.1322

RIG_SCORE: 0.5418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V52M	TCGA-2W-A8YY	CESC	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.0833
p.E42D	TCGA-77-A5GH	LUSC	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.5647
p.E42D	DO45452	LUSC	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.5647
p.R44C	TCGA-A5-A1OF	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.3056
p.T50A	TCGA-AP-A0LM	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.1389
p.T50A	DO43306	UCEC	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.1389
p.G46R	TCGA-BF-A1PX	SKCM	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.25
p.G46R	DO233877	GACA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.25
p.G46R	DO51236	SKCM	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.25
p.E49K	TCGA-EE-A2M5	SKCM	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.1667
p.E49K	DO37425	SKCM	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.1667
p.E32G	TCGA-PG-A917	UCEC	TCGA	DSGPES	DEG_SCF_TRCP1_1	0.1667
p.E32G	DO52424	UCEC	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.1667
p.S45I	DO224768	BRCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.2778
p.G40R	DO234262	ESAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.7568
p.A34V	DO228732	GACA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.2222
p.P41T	DO45267	LIRI	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.5919
p.D38E	DO25847	LUAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.6758
p.A37S	DO231165	LUSC	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.3056
p.A37V	DO220906	MELA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.3056
p.A29T	DO228138	PBCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.0833
p.A44V	DO50418	PRAD	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.3056
p.Q50R	DO229087	THCA	ICGC	DSGPES	DEG_SCF_TRCP1_1	0.1389
p.G33S	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPES	DEG_SCF_TRCP1_1	0.1944
p.G33S	ACH-000509	Lymphoma	CCLE	DSGPES	DEG_SCF_TRCP1_1	0.1944
p.S43N	SIDM00007	Other Solid Cancers	GDSC	DSGPES	DEG_SCF_TRCP1_1	0.818
p.S43N	ACH-001550	Skin Cancer	CCLE	DSGPES	DEG_SCF_TRCP1_1	0.818
p.S43N	MCC13	skin	COSMIC	DSGPES	DEG_SCF_TRCP1_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXA9	Sal-like protein 3	DEG_SCF_TRCP1_1	38:43	DSGPES	BTRC	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPES

Degron related mutations and impact score

Drug responses associated with SALL3 mutations

All proteins holding degron of DSGPES