DegronMD

Uniprot ID: Q9BXA9

Source protein: Sal-like protein 3

Source gene: SALL3

Class: DEG_SCF_FBW7_2

Location: 766:773

E3 ligase: FBXW7

DEGRON score: 0.9797

ASA_SCORE: 67.325

COIL: 0.8195

CONS_SCORE: 0.5562

DSS_SCORE: 0.5857

HELIX: 0.074

FCONS_SCORE: 0.9894

RIG_SCORE: 0.6824

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P772L	TCGA-AP-A1DV	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.6471
p.P772L	TCGA-F4-6570	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.6471
p.R759H	TCGA-B5-A11E	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.R759H	TCGA-CN-4734	HNSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.P770L	TCGA-CA-6718	COAD	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.7582
p.P770L	TCGA-EE-A2MS	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.7582
p.T769M	TCGA-CV-5436	HNSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.7423
p.E782K	TCGA-DA-A1HV	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.0833
p.A778V	TCGA-DI-A1BU	UCEC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.1944
p.M762I	TCGA-EE-A2ME	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.R759S	TCGA-EE-A3AG	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.G763S	TCGA-FR-A726	SKCM	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.25
p.G764R	TCGA-NC-A5HP	LUSC	TCGA	IPNTPLPE	DEG_SCF_FBW7_2	0.2778
p.A762T	DO50575	BOCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.A762T	DO230335	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.A762T	DO233638	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.A762T	DO233624	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.R783C	DO222765	COCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.0556
p.R756H	DO233264	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.0556
p.R756H	DO233672	GACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.0556
p.Q770R	DO15894	HNSC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.7329
p.S760C	DO23672	LUAD	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.1667
p.G759S	DO26963	LUSC	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.S777N	DO51515	PACA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.2222
p.R756C	DO48919	PBCA	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.0556
p.E765K	DO37881	SKCM	ICGC	IPNTPLPE	DEG_SCF_FBW7_2	0.3056
p.R759C	SIDM00944	Colorectal Carcinoma	GDSC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.R759C	ACH-000249	Colon/Colorectal Cancer	CCLE	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.R759C	CL-11	large_intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	0.1389
p.G774S	SIDM00545	Melanoma	GDSC	IPNTPLPE	DEG_SCF_FBW7_2	0.3056
p.G774S	ACH-000987	Skin Cancer	CCLE	IPNTPLPE	DEG_SCF_FBW7_2	0.3056
p.G774S	Mewo	skin	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	0.3056
p.S769L	HT-115	large_intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	0.7667
p.P761L	OVKATE	ovary	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	0.1944
p.L758R	GP5d	large_intestine	COSMIC	IPNTPLPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJQ4	Sal-like protein 4	DEG_SCF_FBW7_2	653:660	IPNTPLPE	FBXW7	0.9843	More...
Q9BXA9	Sal-like protein 3	DEG_SCF_FBW7_2	766:773	IPNTPLPE	FBXW7	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPNTPLPE

Degron related mutations and impact score

Drug responses associated with SALL3 mutations

All proteins holding degron of IPNTPLPE