DegronMD

Uniprot ID: Q9BXA9

Source protein: Sal-like protein 3

Source gene: SALL3

Class: LIG_APCC_ABBA_1

Location: 80:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9908

ASA_SCORE: 78.35

COIL: 0.7388

CONS_SCORE: 0.4296

DSS_SCORE: 0.5121

HELIX: 0.0655

FCONS_SCORE: 1.0758

RIG_SCORE: 0.7365

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S72R	TCGA-51-4080	LUSC	TCGA	LIVHED	LIG_APCC_ABBA_1	0.1111
p.P91T	TCGA-60-2724	LUSC	TCGA	LIVHED	LIG_APCC_ABBA_1	0.1667
p.P91T	DO26540	LUSC	ICGC	LIVHED	LIG_APCC_ABBA_1	0.1667
p.E84G	TCGA-AX-A2HJ	UCEC	TCGA	LIVHED	LIG_APCC_ABBA_1	0.6087
p.E84G	DO42105	UCEC	ICGC	LIVHED	LIG_APCC_ABBA_1	0.6087
p.A88V	TCGA-AX-A3G9	UCEC	TCGA	LIVHED	LIG_APCC_ABBA_1	0.25
p.A88V	DO222467	BTCA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.25
p.A88V	DO23236	LINC	ICGC	LIVHED	LIG_APCC_ABBA_1	0.25
p.A88V	DO46331	OV	ICGC	LIVHED	LIG_APCC_ABBA_1	0.25
p.A88V	DO32992	PACA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.25
p.A88V	DO41241	UCEC	ICGC	LIVHED	LIG_APCC_ABBA_1	0.25
p.L80M	TCGA-BR-8297	STAD	TCGA	LIVHED	LIG_APCC_ABBA_1	0.5999
p.R71W	TCGA-CG-4460	STAD	TCGA	LIVHED	LIG_APCC_ABBA_1	0.0833
p.R71W	DO38427	STAD	ICGC	LIVHED	LIG_APCC_ABBA_1	0.0833
p.E84K	TCGA-FS-A1ZZ	SKCM	TCGA	LIVHED	LIG_APCC_ABBA_1	0.591
p.E84K	DO222402	MELA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.591
p.E84K	DO37412	SKCM	ICGC	LIVHED	LIG_APCC_ABBA_1	0.591
p.A86V	TCGA-HT-A5RC	LGG	TCGA	LIVHED	LIG_APCC_ABBA_1	0.3056
p.A86V	DO48525	LGG	ICGC	LIVHED	LIG_APCC_ABBA_1	0.3056
p.A86V	SIDM00216	Colorectal Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	0.3056
p.A86V	SIDM01511	Gastric Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	0.3056
p.A86V	ACH-000746	Gastric Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	0.3056
p.A86V	ACH-000989	Colon/Colorectal Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	0.3056
p.P89S	TCGA-L9-A5IP	LUAD	TCGA	LIVHED	LIG_APCC_ABBA_1	0.2222
p.P89S	DO49873	LUAD	ICGC	LIVHED	LIG_APCC_ABBA_1	0.2222
p.I81M	TCGA-N6-A4VC	UCS	TCGA	LIVHED	LIG_APCC_ABBA_1	0.6507
p.P91H	DO222990	BTCA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.1667
p.R94S	DO20808	KIRP	ICGC	LIVHED	LIG_APCC_ABBA_1	0.0833
p.A78T	DO50755	LICA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.2778
p.R94H	DO45428	LUSC	ICGC	LIVHED	LIG_APCC_ABBA_1	0.0833
p.P78L	DO220891	MELA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.2778
p.P90H	DO46566	OV	ICGC	LIVHED	LIG_APCC_ABBA_1	0.1944
p.F94S	DO229453	SKCA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.0833
p.F94S	ACH-002368	Non-Cancerous	CCLE	LIVHED	LIG_APCC_ABBA_1	0.0833
p.S95N	DO229211	THCA	ICGC	LIVHED	LIG_APCC_ABBA_1	0.0556
p.P90T	SIDM00919	Ovarian Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	0.1944
p.P90T	ACH-000713	Ovarian Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	0.1944
p.V79M	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	0.3056
p.V79M	ACH-000481	Lung Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	0.3056
p.V79M	NCI-H2170	lung	COSMIC	LIVHED	LIG_APCC_ABBA_1	0.3056
p.P77R	SIDM01140	Ovarian Carcinoma	GDSC	LIVHED	LIG_APCC_ABBA_1	0.25
p.P77R	ACH-001374	Ovarian Cancer	CCLE	LIVHED	LIG_APCC_ABBA_1	0.25
p.P77R	PA-1	ovary	COSMIC	LIVHED	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIVHED

Degron related mutations and impact score

Drug responses associated with SALL3 mutations

All proteins holding degron of LIVHED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXA9	Sal-like protein 3	LIG_APCC_ABBA_1	80:85	LIVHED	APC,CDC20,FZR1	0.9908	More...