DegronMD - A6NMK8(INSYN2B)

INSYN2B

UniProt ID: A6NMK8

Entrez ID: 100131897

Protein name: Protein INSYN2B (Inhibitory synaptic factor family member 2B)

External links: UniprotKB HGNC RefSeq COSMIC

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R240H	SIDM00781	Colorectal Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00362	Burkitt's Lymphoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM01196	Hepatocellular Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00557	Neuroblastoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00487	Colorectal Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00024	Non-Cancerous	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00242	Osteosarcoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00582	Pancreatic Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM01018	Hodgkin's Lymphoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.R240H	SIDM00243	Other Solid Cancers	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation rewiring degron network	0.1389
p.P249L	SIDM01175	Other Sarcomas	GDSC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation altering degron motif	0.7582
p.P249L	SW684	soft tissue	COSMIC	VTPLDS	DEG_SCF_FBW7_1	247:252	Mutation altering degron motif	0.7582
p.K67N	SIDM00255	Neuroblastoma	GDSC	PPTY	ITCH	76:79	Mutation substituting flanking lysine	0.1944
p.K67N	NB17	autonomic ganglia	COSMIC	PPTY	ITCH	76:79	Mutation substituting flanking lysine	0.1944
p.P77T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	76:79	Mutation altering degron motif	0.7031
p.P77T	H513	pleura	COSMIC	PPTY	ITCH	76:79	Mutation altering degron motif	0.7031

Kaplan plot for INSYN2B in

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*NOTE: the Kaplan plots were collected from OncoLnc