DegronMD

Uniprot ID: A6NMK8

Source protein: Protein INSYN2B

Source gene: INSYN2B

Class: DEG_SCF_FBW7_1

Location: 247:252

E3 ligase: FBXW7

DEGRON score: 0.7866

ASA_SCORE: 81.6833

COIL: 0.84

CONS_SCORE: 0.3337

DSS_SCORE: 0.663

HELIX: 0.089

FCONS_SCORE: 0.7642

RIG_SCORE: 0.6819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R240H	SIDM00781	Colorectal Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00362	Burkitt's Lymphoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM01196	Hepatocellular Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00557	Neuroblastoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00487	Colorectal Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00024	Non-Cancerous	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00242	Osteosarcoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00582	Pancreatic Carcinoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM01018	Hodgkin's Lymphoma	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.R240H	SIDM00243	Other Solid Cancers	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.1389
p.P249L	SIDM01175	Other Sarcomas	GDSC	VTPLDS	DEG_SCF_FBW7_1	0.7582
p.P249L	SW684	soft_tissue	COSMIC	VTPLDS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NMK8	Protein INSYN2B	DEG_SCF_FBW7_1	247:252	VTPLDS	FBXW7	0.7866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons