DegronMD - P25391(LAMA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S3048G	TCGA-24-2267	OV	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation blocking phosphorylation signal	0.6667
p.S3048G	DO29740	OV	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation blocking phosphorylation signal	0.6667
p.P172A	TCGA-42-2591	OV	TCGA	PPTY	ITCH	171:174	Mutation altering degron motif	0.7503
p.P172A	DO31654	OV	ICGC	PPTY	ITCH	171:174	Mutation altering degron motif	0.7503
p.P172T	TCGA-55-8507	LUAD	TCGA	PPTY	ITCH	171:174	Mutation altering degron motif	0.7031
p.P172T	DO45412	LUAD	ICGC	PPTY	ITCH	171:174	Mutation altering degron motif	0.7031
p.R162G	TCGA-AC-A23H	BRCA	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162G	DO2401	BRCA	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R382T	TCGA-AG-A036	READ	TCGA	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.2222
p.R382T	DO37245	READ	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.2222
p.R162H	TCGA-AJ-A3BH	UCEC	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	TCGA-D5-5540	COAD	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	DO8738	COAD	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	DO41638	UCEC	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	SIDM00473	Oral Cavity Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	SIDM00874	Breast Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	SIDM00873	Non-Cancerous	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R162H	SIDM00613	Glioblastoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0833
p.R175M	TCGA-AX-A1CE	UCEC	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.R175M	DO42280	UCEC	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.R3037C	TCGA-BK-A13B	UCEC	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R3037C	TCGA-BS-A0UV	UCEC	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R3037C	DO234384	ESAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R3037C	DO220866	MELA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R3037C	DO40825	UCEC	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R3037C	DO42793	UCEC	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8301
p.R168G	TCGA-BR-6453	STAD	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.25
p.R168G	DO38543	STAD	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.25
p.K385N	TCGA-BR-7197	STAD	TCGA	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.3056
p.K385N	DO38839	STAD	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.3056
p.R3037H	TCGA-CM-4743	COAD	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8244
p.R3037H	DO8103	COAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8244
p.R3037H	SIDM00792	Small Cell Lung Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8244
p.R3037H	NCI-H1688	lung	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.8244
p.S184Y	TCGA-D3-A2JB	SKCM	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0556
p.S184Y	DO47607	SKCM	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.0556
p.R3041M	TCGA-D3-A2JK	SKCM	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.7521
p.R3041M	DO37619	SKCM	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation altering degron motif	0.7521
p.D400N	TCGA-DX-AB2E	SARC	TCGA	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.0833
p.D400N	DO220073	SARC	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.0833
p.E179K	TCGA-EE-A29L	SKCM	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.1944
p.E179K	DO222599	MELA	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.1944
p.E179K	DO37835	SKCM	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.1944
p.S3035L	TCGA-EE-A2MJ	SKCM	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.3056
p.S3035L	DO233903	GACA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.3056
p.S3035L	DO38099	SKCM	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.3056
p.R3031H	TCGA-EW-A1OZ	BRCA	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944
p.R3031H	DO3834	BRCA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944
p.R3031H	SIDM00673	Breast Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944
p.R3031H	ACH-000668	Breast Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944
p.R3031H	HCC70	breast	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944
p.Y380H	TCGA-HU-A4H3	STAD	TCGA	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.1667
p.Y380H	DO47903	STAD	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.1667
p.V3051A	TCGA-IN-7806	STAD	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1389
p.V3051A	DO38831	STAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1389
p.R169Q	TCGA-XP-A8T7	ESCA	TCGA	PPTY	ITCH	171:174	Mutation rewiring degron network	0.2778
p.R169Q	SIDM01121	Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.2778
p.R169Q	ACH-000358	Lung Cancer	CCLE	PPTY	ITCH	171:174	Mutation rewiring degron network	0.2778
p.R169Q	NCI-H69	lung	COSMIC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.2778
p.R395C	DO234261	ESAD	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.2222
p.P167A	DO233193	GACA	ICGC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.2222
p.D378E	DO231515	LINC	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.1111
p.C399F	DO23186	LINC	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.1111
p.S3053F	DO220899	MELA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation blocking phosphorylation signal	0.5278
p.P388S	DO37782	SKCM	ICGC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation altering degron motif	0.6752
p.P401S	SIDM01314	Colorectal Carcinoma	GDSC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation rewiring degron network	0.0556
p.G170V	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.G170V	NCI-H1944	lung	COSMIC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.P388T	SIDM00672	Hepatocellular Carcinoma	GDSC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation altering degron motif	0.7031
p.P388T	ACH-000625	Liver Cancer	CCLE	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation altering degron motif	0.7031
p.P388T	Hep_3B2_1-7	NS	COSMIC	VSPYED	LIG_APCC_ABBA_1	386:391	Mutation altering degron motif	0.7031
p.G170W	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.G170W	ACH-000414	Lung Cancer	CCLE	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.G170W	NCI-H1944	lung	COSMIC	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.Q3033L	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.25
p.Q3033L	ACH-000496	Lung Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.25
p.Q3033L	NCI-H1792	lung	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.25
p.T173P	SIDM00090	Ovarian Carcinoma	GDSC	PPTY	ITCH	171:174	Mutation altering degron motif	0.5919
p.T173P	ACH-000696	Ovarian Cancer	CCLE	PPTY	ITCH	171:174	Mutation altering degron motif	0.5919
p.T173P	OVCAR-8	ovary	COSMIC	PPTY	ITCH	171:174	Mutation altering degron motif	0.5919
p.S3032R	SIDM00251	Gastric Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.2222
p.S3032R	ACH-000949	Gastric Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.2222
p.S3032R	TGBC11TKB	stomach	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.2222
p.Q3027K	ACH-000097	Breast Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.0833
p.G170L	ACH-000414	Lung Cancer	CCLE	PPTY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.P3049L	ACH-000588	Myeloma	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	3036:3044	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAMA1

UniProt ID: P25391

Entrez ID: 284217

Protein name: Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAMA1 in