DegronMD

Uniprot ID: P25391

Source protein: Laminin subunit alpha-1

Source gene: LAMA1

Class: DEG_APCC_DBOX_1

Location: 3036:3044

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7184

ASA_SCORE: 34.2444

COIL: 0.1802

CONS_SCORE: 0.3944

DSS_SCORE: 0.1224

HELIX: 0.0239

FCONS_SCORE: 1.4069

RIG_SCORE: 0.886

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3048G	TCGA-24-2267	OV	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.6667
p.S3048G	DO29740	OV	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.6667
p.R3037C	TCGA-BK-A13B	UCEC	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037C	TCGA-BS-A0UV	UCEC	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037C	DO234384	ESAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037C	DO220866	MELA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037C	DO40825	UCEC	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037C	DO42793	UCEC	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8301
p.R3037H	TCGA-CM-4743	COAD	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.8244
p.R3037H	DO8103	COAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8244
p.R3037H	SIDM00792	Small Cell Lung Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8244
p.R3037H	NCI-H1688	lung	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	0.8244
p.R3041M	TCGA-D3-A2JK	SKCM	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.7521
p.R3041M	DO37619	SKCM	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.7521
p.S3035L	TCGA-EE-A2MJ	SKCM	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.3056
p.S3035L	DO233903	GACA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.3056
p.S3035L	DO38099	SKCM	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.3056
p.R3031H	TCGA-EW-A1OZ	BRCA	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944
p.R3031H	DO3834	BRCA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944
p.R3031H	SIDM00673	Breast Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944
p.R3031H	ACH-000668	Breast Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944
p.R3031H	HCC70	breast	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944
p.V3051A	TCGA-IN-7806	STAD	TCGA	FRGCLRKLA	DEG_APCC_DBOX_1	0.1389
p.V3051A	DO38831	STAD	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.1389
p.S3053F	DO220899	MELA	ICGC	FRGCLRKLA	DEG_APCC_DBOX_1	0.5278
p.Q3033L	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	0.25
p.Q3033L	ACH-000496	Lung Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	0.25
p.Q3033L	NCI-H1792	lung	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	0.25
p.S3032R	SIDM00251	Gastric Carcinoma	GDSC	FRGCLRKLA	DEG_APCC_DBOX_1	0.2222
p.S3032R	ACH-000949	Gastric Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	0.2222
p.S3032R	TGBC11TKB	stomach	COSMIC	FRGCLRKLA	DEG_APCC_DBOX_1	0.2222
p.Q3027K	ACH-000097	Breast Cancer	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	0.0833
p.P3049L	ACH-000588	Myeloma	CCLE	FRGCLRKLA	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRGCLRKLA

Degron related mutations and impact score

Drug responses associated with LAMA1 mutations

All proteins holding degron of FRGCLRKLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25391	Laminin subunit alpha-1	DEG_APCC_DBOX_1	3036:3044	FRGCLRKLA	APC,CDC20,FZR1	0.7184	More...