DegronMD

Uniprot ID: P25391

Source protein: Laminin subunit alpha-1

Source gene: LAMA1

Class: ITCH

Location: 171:174

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9366

ASA_SCORE: 76.625

COIL: 0.9263

CONS_SCORE: 0.3986

DSS_SCORE: 0.3694

HELIX: 0.013

FCONS_SCORE: 0.8197

RIG_SCORE: 0.7097

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P172A	TCGA-42-2591	OV	TCGA	PPTY	ITCH	0.7503
p.P172A	DO31654	OV	ICGC	PPTY	ITCH	0.7503
p.P172T	TCGA-55-8507	LUAD	TCGA	PPTY	ITCH	0.7031
p.P172T	DO45412	LUAD	ICGC	PPTY	ITCH	0.7031
p.R162G	TCGA-AC-A23H	BRCA	TCGA	PPTY	ITCH	0.0833
p.R162G	DO2401	BRCA	ICGC	PPTY	ITCH	0.0833
p.R162H	TCGA-AJ-A3BH	UCEC	TCGA	PPTY	ITCH	0.0833
p.R162H	TCGA-D5-5540	COAD	TCGA	PPTY	ITCH	0.0833
p.R162H	DO8738	COAD	ICGC	PPTY	ITCH	0.0833
p.R162H	DO41638	UCEC	ICGC	PPTY	ITCH	0.0833
p.R162H	SIDM00473	Oral Cavity Carcinoma	GDSC	PPTY	ITCH	0.0833
p.R162H	SIDM00874	Breast Carcinoma	GDSC	PPTY	ITCH	0.0833
p.R162H	SIDM00873	Non-Cancerous	GDSC	PPTY	ITCH	0.0833
p.R162H	SIDM00613	Glioblastoma	GDSC	PPTY	ITCH	0.0833
p.R175M	TCGA-AX-A1CE	UCEC	TCGA	PPTY	ITCH	0.3056
p.R175M	DO42280	UCEC	ICGC	PPTY	ITCH	0.3056
p.R168G	TCGA-BR-6453	STAD	TCGA	PPTY	ITCH	0.25
p.R168G	DO38543	STAD	ICGC	PPTY	ITCH	0.25
p.S184Y	TCGA-D3-A2JB	SKCM	TCGA	PPTY	ITCH	0.0556
p.S184Y	DO47607	SKCM	ICGC	PPTY	ITCH	0.0556
p.E179K	TCGA-EE-A29L	SKCM	TCGA	PPTY	ITCH	0.1944
p.E179K	DO222599	MELA	ICGC	PPTY	ITCH	0.1944
p.E179K	DO37835	SKCM	ICGC	PPTY	ITCH	0.1944
p.R169Q	TCGA-XP-A8T7	ESCA	TCGA	PPTY	ITCH	0.2778
p.R169Q	SIDM01121	Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	0.2778
p.R169Q	ACH-000358	Lung Cancer	CCLE	PPTY	ITCH	0.2778
p.R169Q	NCI-H69	lung	COSMIC	PPTY	ITCH	0.2778
p.P167A	DO233193	GACA	ICGC	PPTY	ITCH	0.2222
p.G170V	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	0.3056
p.G170V	NCI-H1944	lung	COSMIC	PPTY	ITCH	0.3056
p.G170W	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	0.3056
p.G170W	ACH-000414	Lung Cancer	CCLE	PPTY	ITCH	0.3056
p.G170W	NCI-H1944	lung	COSMIC	PPTY	ITCH	0.3056
p.T173P	SIDM00090	Ovarian Carcinoma	GDSC	PPTY	ITCH	0.5919
p.T173P	ACH-000696	Ovarian Cancer	CCLE	PPTY	ITCH	0.5919
p.T173P	OVCAR-8	ovary	COSMIC	PPTY	ITCH	0.5919
p.G170L	ACH-000414	Lung Cancer	CCLE	PPTY	ITCH	0.3056

Drug responses associated with LAMA1 mutations

All proteins holding degron of PPTY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	ITCH	3280:3283	PPTY	ITCH,NEDD4	0.9968	More...
O14514	Adhesion G protein-coupled receptor B1	ITCH	628:631	PPTY	ITCH,NEDD4	0.9223	More...
O14578	Citron Rho-interacting kinase	ITCH	1926:1929	PPTY	ITCH,NEDD4	0.5412	More...
O14686	Histone-lysine N-methyltransferase 2D	ITCH	2193:2196	PPTY	ITCH,NEDD4	0.9967	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	252:255	PPTY	ITCH,NEDD4	0.9918	More...
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ITCH	658:661	PPTY	ITCH,NEDD4	0.6551	More...
O75175	CCR4-NOT transcription complex subunit 3	ITCH	320:323	PPTY	ITCH,NEDD4	0.7287	More...
O75909	Cyclin-K	ITCH	510:513	PPTY	ITCH,NEDD4	0.7979	More...
P21796	Voltage-dependent anion-selective channel protein 1	ITCH	4:7	PPTY	ITCH,NEDD4	0.5246	More...
P23759	Paired box protein Pax-7	ITCH	444:447	PPTY	ITCH,NEDD4	0.9893	More...
P23760	Paired box protein Pax-3	ITCH	450:453	PPTY	ITCH,NEDD4	0.9541	More...
P25391	Laminin subunit alpha-1	ITCH	171:174	PPTY	ITCH,NEDD4	0.9366	More...
P82650	28S ribosomal protein S22, mitochondrial	ITCH	100:103	PPTY	ITCH,NEDD4	0.9899	More...
Q00341	Vigilin	ITCH	37:40	PPTY	ITCH,NEDD4	0.6855	More...
Q01892	Transcription factor Spi-B	ITCH	80:83	PPTY	ITCH,NEDD4	0.9975	More...
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ITCH	116:119	PPTY	ITCH,NEDD4	0.9984	More...
Q13459	Unconventional myosin-IXb	ITCH	2143:2146	PPTY	ITCH,NEDD4	0.9285	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	1581:1584	PPTY	ITCH,NEDD4	0.9943	More...
Q7Z478	ATP-dependent RNA helicase DHX29	ITCH	459:462	PPTY	ITCH,NEDD4	0.8751	More...
Q86U70	LIM domain-binding protein 1	ITCH	49:52	PPTY	ITCH,NEDD4	0.9966	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	ITCH	41:44	PPTY	ITCH,NEDD4	0.9955	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	ITCH	666:669	PPTY	ITCH,NEDD4	0.8045	More...
Q92859	Neogenin	ITCH	1372:1375	PPTY	ITCH,NEDD4	0.9601	More...
Q93050	V-type proton ATPase 116 kDa subunit a 1	ITCH	361:364	PPTY	ITCH,NEDD4	0.9108	More...
Q969W9	Protein TMEPAI	ITCH	229:232	PPTY	ITCH,NEDD4	0.9995	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	ITCH	416:419	PPTY	ITCH,NEDD4	0.9553	More...
Q9BRG2	SH2 domain-containing protein 3A	ITCH	228:231	PPTY	ITCH,NEDD4	0.9875	More...
Q9BSA4	Protein tweety homolog 2	ITCH	506:509	PPTY	ITCH,NEDD4	0.9004	More...
Q9BT40	Inositol polyphosphate 5-phosphatase K	ITCH	244:247	PPTY	ITCH,NEDD4	0.9245	More...
Q9H3M7	Thioredoxin-interacting protein	ITCH	375:378	PPTY	ITCH,NEDD4	0.9994	More...
Q9H6T0	Epithelial splicing regulatory protein 2	ITCH	584:587	PPTY	ITCH,NEDD4	0.9502	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4182:4185	PPTY	ITCH,NEDD4	0.9282	More...
Q9P2K8	eIF-2-alpha kinase GCN2	ITCH	80:83	PPTY	ITCH,NEDD4	0.7591	More...
Q9UJQ4	Sal-like protein 4	ITCH	833:836	PPTY	ITCH,NEDD4	0.9797	More...
Q9UPA5	Protein bassoon	ITCH	1952:1955	PPTY	ITCH,NEDD4	0.8543	More...
Q9Y6I3	Epsin-1	ITCH	545:548	PPTY	ITCH,NEDD4	0.7626	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	169:172	PPTY	ITCH,NEDD4	0.998	More...
Q5JSZ5	Protein PRRC2B	ITCH	275:278	PPTY	ITCH,NEDD4	0.8146	More...
Q9UKU9	Angiopoietin-related protein 2	ITCH	227:230	PPTY	ITCH,NEDD4	0.7151	More...
Q96K62	Zinc finger and BTB domain-containing protein 45	ITCH	400:403	PPTY	ITCH,NEDD4	0.7412	More...
A6NMK8	Protein INSYN2B	ITCH	76:79	PPTY	ITCH,NEDD4	0.8124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTY

Degron related mutations and impact score

Drug responses associated with LAMA1 mutations

All proteins holding degron of PPTY