DegronMD - Q8IXZ2(ZC3H3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A872S	TCGA-56-7222	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.7588
p.A872S	DO26842	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.7588
p.K360T	TCGA-B0-5104	KIRC	TCGA	PATSS	DEG_SPOP_SBC_1	364:368	Mutation substituting flanking lysine	0.3333
p.K360T	DO16955	KIRC	ICGC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation substituting flanking lysine	0.3333
p.R393C	TCGA-BR-6452	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.R393C	DO234462	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.R393C	DO38404	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.P384S	TCGA-D7-A4YT	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.P384S	DO47723	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.P867L	TCGA-EB-A553	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1944
p.P867L	DO47329	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1944
p.R53L	TCGA-MP-A4TF	LUAD	TCGA	PPTY	ITCH	41:44	Mutation rewiring degron network	0.0833
p.R53L	DO45316	LUAD	ICGC	PPTY	ITCH	41:44	Mutation rewiring degron network	0.0833
p.S388F	TCGA-R5-A7ZE	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7982
p.S388F	DO222340	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7982
p.S879Y	TCGA-S9-A6U6	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S879Y	DO50190	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S879Y	DO229018	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.P29L	TCGA-VS-A94W	CESC	TCGA	PGTPAAS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.2778
p.P29L	DO219726	CESC	ICGC	PGTPAAS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.2778
p.S375R	DO228290	BRCA	ICGC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.S399G	DO230334	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.S399G	DO229013	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.S399G	DO229003	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.S399G	DO229505	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.S399G	DO230522	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.G47D	DO227802	COCA	ICGC	PGTPAAS	DEG_SCF_FBW7_1	31:37	Mutation rewiring degron network	0.0556
p.G47D	DO227802	COCA	ICGC	PPTY	ITCH	41:44	Mutation rewiring degron network	0.25
p.S880T	DO229010	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.S880T	DO229016	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.S880T	DO229003	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.2222
p.K378T	DO228536	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation substituting flanking lysine	0.1667
p.K378T	DO228536	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation substituting flanking lysine	0.2222
p.S879T	DO229018	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S879F	DO229177	LMS	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S879F	SIDM00909	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.S879F	ACH-000644	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.25
p.P364S	DO232353	PBCA	ICGC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6752
p.S874F	DO229462	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation altering degron motif	0.7982
p.P867H	DO229234	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1944
p.A884T	SIDM02039	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	872:876	Mutation rewiring degron network	0.1111
p.R393H	SIDM01290	Esophageal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.D356N	SIDM00680	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1111
p.D356N	ACH-000957	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1111
p.D356N	LS-180	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1111
p.A386T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7139
p.A373T	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1944
p.A373T	ACH-000672	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1944
p.A373T	IA-LM	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1944
p.S368F	ACH-001407	Bladder Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H3

UniProt ID: Q8IXZ2

Entrez ID: 23144

Protein name: Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H3 in