DegronMD

Uniprot ID: Q8IXZ2

Source protein: Zinc finger CCCH domain-containing protein 3

Source gene: ZC3H3

Class: DEG_SCF_FBW7_1

Location: 31:37

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 76.0571

COIL: 0.9334

CONS_SCORE: 0.4405

DSS_SCORE: 0.6045

HELIX: 0.0387

FCONS_SCORE: 0.9455

RIG_SCORE: 0.5922

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P29L	TCGA-VS-A94W	CESC	TCGA	PGTPAAS	DEG_SCF_FBW7_1	0.2778
p.P29L	DO219726	CESC	ICGC	PGTPAAS	DEG_SCF_FBW7_1	0.2778
p.G47D	DO227802	COCA	ICGC	PGTPAAS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SCF_FBW7_1	31:37	PGTPAAS	FBXW7	0.9887	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons