DegronMD - Q9Y6I3(EPN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K555N	TCGA-55-7994	LUAD	TCGA	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1389
p.P459L	TCGA-AG-A026	READ	TCGA	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.7582
p.P464R	TCGA-AQ-A0Y5	BRCA	TCGA	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.7512
p.P469R	TCGA-CJ-6028	KIRC	TCGA	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation blocking ubiquitination signal	0.6389
p.T550A	TCGA-HC-A8CY	PRAD	TCGA	PPTY	ITCH	545:548	Mutation rewiring degron network	0.2778
p.A545V	TCGA-IB-7651	PAAD	TCGA	PPTY	ITCH	545:548	Mutation altering degron motif	0.6936
p.T548A	TCGA-L5-A8NH	ESCA	TCGA	PPTY	ITCH	545:548	Mutation altering degron motif	0.7139
p.S550C	DO51632	CESC	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.2778
p.P538L	DO10132	COAD	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1389
p.P538L	DO8858	COAD	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1389
p.Y548H	DO7918	COAD	ICGC	PPTY	ITCH	545:548	Mutation altering degron motif	0.834
p.A544V	DO233833	GACA	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.3056
p.P540A	DO52034	HNSC	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1944
p.G554V	DO26328	LUAD	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1667
p.Y548F	DO223722	LUSC	ICGC	PPTY	ITCH	545:548	Mutation altering degron motif	0.8639
p.P551S	DO220899	MELA	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.25
p.P542S	DO222753	MELA	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.25
p.P542S	DO38099	SKCM	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.25
p.G450R	DO28641	OV	ICGC	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1389
p.L449M	DO42033	UCEC	ICGC	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1111
p.G554R	DO42977	UCEC	ICGC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1667
p.G554R	OC-314	ovary	COSMIC	PPTY	ITCH	545:548	Mutation rewiring degron network	0.1667
p.P457L	SIDM01314	Colorectal Carcinoma	GDSC	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6471
p.P457S	SIDM01174	Cervical Carcinoma	GDSC	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6752
p.P457S	SW756	cervix	COSMIC	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation altering degron motif	0.6752
p.V452A	ACH-001345	Colon/Colorectal Cancer	CCLE	PAATPTPT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1944

Kaplan plot for EPN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPN1

UniProt ID: Q9Y6I3

Entrez ID: 29924

Protein name: Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EPN1 in