DegronMD

Uniprot ID: Q9Y6I3

Source protein: Epsin-1

Source gene: EPN1

Class: DEG_SCF_FBW7_1

Location: 457:464

E3 ligase: FBXW7

DEGRON score: 0.9715

ASA_SCORE: 95.475

COIL: 0.9734

CONS_SCORE: 0.2669

DSS_SCORE: 0.7737

HELIX: 0.0084

FCONS_SCORE: 0.8293

RIG_SCORE: 0.557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P459L	TCGA-AG-A026	READ	TCGA	PAATPTPT	DEG_SCF_FBW7_1	0.7582
p.P464R	TCGA-AQ-A0Y5	BRCA	TCGA	PAATPTPT	DEG_SCF_FBW7_1	0.7512
p.P469R	TCGA-CJ-6028	KIRC	TCGA	PAATPTPT	DEG_SCF_FBW7_1	0.6389
p.G450R	DO28641	OV	ICGC	PAATPTPT	DEG_SCF_FBW7_1	0.1389
p.L449M	DO42033	UCEC	ICGC	PAATPTPT	DEG_SCF_FBW7_1	0.1111
p.P457L	SIDM01314	Colorectal Carcinoma	GDSC	PAATPTPT	DEG_SCF_FBW7_1	0.6471
p.P457S	SIDM01174	Cervical Carcinoma	GDSC	PAATPTPT	DEG_SCF_FBW7_1	0.6752
p.P457S	SW756	cervix	COSMIC	PAATPTPT	DEG_SCF_FBW7_1	0.6752
p.V452A	ACH-001345	Colon/Colorectal Cancer	CCLE	PAATPTPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6I3	Epsin-1	DEG_SCF_FBW7_1	457:464	PAATPTPT	FBXW7	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons