DegronMD - Q9BRG2(SH2D3A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A187P	TCGA-AX-A1C9	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1389
p.A187P	DO43098	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1389
p.S225C	TCGA-C5-A1BK	CESC	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.1944
p.S225C	TCGA-C5-A1BK	CESC	TCGA	PPTY	ITCH	228:231	Mutation rewiring degron network	0.25
p.S225C	DO6266	CESC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.1944
p.S225C	DO6266	CESC	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.25
p.S168F	TCGA-CV-A45P	HNSC	TCGA	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1111
p.S168F	DO219026	HNSC	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1111
p.P214S	TCGA-D3-A8GI	SKCM	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.5641
p.P214S	DO50284	SKCM	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.5641
p.P228H	TCGA-DF-A2KU	UCEC	TCGA	PPTY	ITCH	228:231	Mutation altering degron motif	0.7694
p.P228H	DO223286	UCEC	ICGC	PPTY	ITCH	228:231	Mutation altering degron motif	0.7694
p.E220K	TCGA-DK-A6AW	BLCA	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7022
p.E220K	DO48566	BLCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.7022
p.P229Q	TCGA-FR-A7UA	SKCM	TCGA	PPTY	ITCH	228:231	Mutation altering degron motif	0.7035
p.P229Q	DO51253	SKCM	ICGC	PPTY	ITCH	228:231	Mutation altering degron motif	0.7035
p.S173C	TCGA-XR-A8TF	LIHC	TCGA	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.S173C	DO223923	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.V241I	DO230309	COCA	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.0556
p.D223G	DO229010	COCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.25
p.D223G	DO229010	COCA	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.1944
p.P190S	DO229505	LAML	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556
p.P239T	DO228948	LICA	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.1111
p.P182Q	DO228974	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P236T	DO229045	LICA	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.1944
p.Q204K	DO23210	LINC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.0833
p.K212T	DO23200	LINC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.3056
p.P171L	DO220913	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1944
p.P171H	DO50724	ORCA	ICGC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1944
p.P222H	DO232761	PBCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2778
p.P222H	DO232761	PBCA	ICGC	PPTY	ITCH	228:231	Mutation rewiring degron network	0.1667
p.A209T	SIDM00578	Neuroblastoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM00435	Acute Myeloid Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM01093	Cervical Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM00365	Small Cell Lung Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM00217	Colorectal Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM00380	Acute Myeloid Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM00274	Gastric Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM01460	Glioma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.A209T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation rewiring degron network	0.2222
p.R177G	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.6457
p.R177G	ACH-000186	Lung Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.6457
p.R177G	NCI-H2444	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.6457
p.S173T	SIDM00656	Burkitt's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.S173T	SIDM00971	Breast Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.S173T	SIDM00257	Neuroblastoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.S173T	SIDM00641	Burkitt's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.25
p.R215Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.6218
p.R215Q	ACH-002256	Leukemia	CCLE	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.6218
p.P182L	SIDM00923	Cervical Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P182L	ACH-001336	Cervical Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.P182L	Ca-Ski	cervix	COSMIC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.2778
p.A187D	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1389
p.A187D	ACH-000158	Lymphoma	CCLE	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1389
p.K208Q	ACH-000044	Breast Cancer	CCLE	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation substituting flanking lysine	0.3056
p.E176K	SW684	soft tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.7022
p.G185V	CW-2	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1944
p.R217W	SNU-1040	large intestine	COSMIC	PPRTPSFE	DEG_SCF_FBW7_2	213:220	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2D3A

UniProt ID: Q9BRG2

Entrez ID: 10045

Protein name: SH2 domain-containing protein 3A (Novel SH2-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2D3A in