DegronMD

Uniprot ID: Q9BRG2

Source protein: SH2 domain-containing protein 3A

Source gene: SH2D3A

Class: DEG_SCF_FBW7_2

Location: 213:220

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 87.4875

COIL: 0.9151

CONS_SCORE: 0.5173

DSS_SCORE: 0.7387

HELIX: 0.058

FCONS_SCORE: 1.067

RIG_SCORE: 0.6161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S225C	TCGA-C5-A1BK	CESC	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	0.1944
p.S225C	DO6266	CESC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.1944
p.P214S	TCGA-D3-A8GI	SKCM	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	0.5641
p.P214S	DO50284	SKCM	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.5641
p.E220K	TCGA-DK-A6AW	BLCA	TCGA	PPRTPSFE	DEG_SCF_FBW7_2	0.7022
p.E220K	DO48566	BLCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.7022
p.D223G	DO229010	COCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.25
p.Q204K	DO23210	LINC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.0833
p.K212T	DO23200	LINC	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.3056
p.P222H	DO232761	PBCA	ICGC	PPRTPSFE	DEG_SCF_FBW7_2	0.2778
p.A209T	SIDM00578	Neuroblastoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM00435	Acute Myeloid Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM01093	Cervical Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM00365	Small Cell Lung Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM00217	Colorectal Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM00380	Acute Myeloid Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM00274	Gastric Carcinoma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM01460	Glioma	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.A209T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.2222
p.R215Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPRTPSFE	DEG_SCF_FBW7_2	0.6218
p.R215Q	ACH-002256	Leukemia	CCLE	PPRTPSFE	DEG_SCF_FBW7_2	0.6218
p.K208Q	ACH-000044	Breast Cancer	CCLE	PPRTPSFE	DEG_SCF_FBW7_2	0.3056
p.R217W	SNU-1040	large_intestine	COSMIC	PPRTPSFE	DEG_SCF_FBW7_2	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRG2	SH2 domain-containing protein 3A	DEG_SCF_FBW7_2	213:220	PPRTPSFE	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons