DegronMD

Uniprot ID: Q9BRG2

Source protein: SH2 domain-containing protein 3A

Source gene: SH2D3A

Class: DEG_SPOP_SBC_1

Location: 176:180

E3 ligase: SPOP

DEGRON score: 0.9677

ASA_SCORE: 89.06

COIL: 0.9236

CONS_SCORE: 0.468

DSS_SCORE: 0.5176

HELIX: 0.0368

FCONS_SCORE: 0.9521

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A187P	TCGA-AX-A1C9	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.A187P	DO43098	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.S168F	TCGA-CV-A45P	HNSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1111
p.S168F	DO219026	HNSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.S173C	TCGA-XR-A8TF	LIHC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.S173C	DO223923	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.P190S	DO229505	LAML	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P182Q	DO228974	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.P171L	DO220913	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P171H	DO50724	ORCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.R177G	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.6457
p.R177G	ACH-000186	Lung Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.6457
p.R177G	NCI-H2444	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.6457
p.S173T	SIDM00656	Burkitt's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.25
p.S173T	SIDM00971	Breast Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.25
p.S173T	SIDM00257	Neuroblastoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.25
p.S173T	SIDM00641	Burkitt's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.25
p.P182L	SIDM00923	Cervical Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.P182L	ACH-001336	Cervical Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.2778
p.P182L	Ca-Ski	cervix	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.A187D	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.A187D	ACH-000158	Lymphoma	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1389
p.E176K	SW684	soft_tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.7022
p.G185V	CW-2	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with SH2D3A mutations

All proteins holding degron of PRTSS