FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 ...
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122}.
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GO - Biological processes (BP):
heart development [GO:0007507]; negative regulation of autophagy [GO:0010507]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496]...
heart development [GO:0007507]; negative regulation of autophagy [GO:0010507]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496]
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GO - Molecular function (MF):
K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]...
K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]...
cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
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