DegronMD

Uniprot ID: Q9NYJ8

Source protein: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Source gene: TAB2

Class: DEG_SCF_FBW7_1

Location: 219:225

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 80.6

COIL: 0.9231

CONS_SCORE: 0.3842

DSS_SCORE: 0.5746

HELIX: 0.013

FCONS_SCORE: 0.879

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q209H	TCGA-A6-3809	COAD	TCGA	ITTPGGT	DEG_SCF_FBW7_1	0.0556
p.Q209H	DO8722	COAD	ICGC	ITTPGGT	DEG_SCF_FBW7_1	0.0556
p.Q228H	DO229025	LICA	ICGC	ITTPGGT	DEG_SCF_FBW7_1	0.25
p.W235C	SIDM00767	Small Cell Lung Carcinoma	GDSC	ITTPGGT	DEG_SCF_FBW7_1	0.0556
p.W235C	ACH-001136	Lung Cancer	CCLE	ITTPGGT	DEG_SCF_FBW7_1	0.0556
p.W235C	NCI-H187	lung	COSMIC	ITTPGGT	DEG_SCF_FBW7_1	0.0556
p.G234V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ITTPGGT	DEG_SCF_FBW7_1	0.0833
p.G234V	ACH-000852	Lung Cancer	CCLE	ITTPGGT	DEG_SCF_FBW7_1	0.0833
p.G234V	NCI-H1435	lung	COSMIC	ITTPGGT	DEG_SCF_FBW7_1	0.0833
p.T221A	ACH-001688	Kidney Cancer	CCLE	ITTPGGT	DEG_SCF_FBW7_1	0.7139
p.T223M	IGROV-1	ovary	COSMIC	ITTPGGT	DEG_SCF_FBW7_1	0.7423
p.P210R	PA-TU-8988T	pancreas	COSMIC	ITTPGGT	DEG_SCF_FBW7_1	0.0833
p.V230M	OVK-18	ovary	COSMIC	ITTPGGT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SCF_FBW7_1	219:225	ITTPGGT	FBXW7	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons