DegronMD

Uniprot ID: Q03111

Source protein: Protein ENL

Source gene: MLLT1

Class: DEG_SPOP_SBC_1

Location: 316:320

E3 ligase: SPOP

DEGRON score: 0.7245

ASA_SCORE: 95.62

COIL: 0.9254

CONS_SCORE: 0.4593

DSS_SCORE: 0.7167

HELIX: 0.0378

FCONS_SCORE: 0.951

RIG_SCORE: 0.4961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S310N	TCGA-2W-A8YY	CESC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6111
p.S310N	DO223732	CESC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6111
p.S315L	TCGA-90-A4EE	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.75
p.S315L	DO45513	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.75
p.S325L	TCGA-A6-2686	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6389
p.S325L	DO7828	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6389
p.A311V	TCGA-AJ-A3EL	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1944
p.A311V	DO41542	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.S325P	TCGA-AP-A1DK	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6389
p.S325P	DO42033	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6389
p.R317C	TCGA-B5-A11E	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.719
p.R317C	DO41644	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.719
p.R309W	TCGA-D3-A2JF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.R309W	DO38153	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.P316H	TCGA-D3-A3C7	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7694
p.P316H	DO47569	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7694
p.P312Q	TCGA-EM-A22J	THCA	TCGA	PRTSS	DEG_SPOP_SBC_1	0.2222
p.P312Q	DO39096	THCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2222
p.G307W	TCGA-FS-A1ZP	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0833
p.G307W	DO37703	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.K327N	TCGA-G7-6797	KIRP	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.K327N	DO20917	KIRP	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.R309Q	DO227549	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.S323F	DO229062	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6944
p.R317H	DO228842	PBCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7133
p.A330S	SIDM00889	Cervical Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.A330S	C-33-A	cervix	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.S322F	SIDM01765	Osteosarcoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with MLLT1 mutations

All proteins holding degron of PRTSS