DegronMD

Uniprot ID: Q9ULC8

Source protein: Palmitoyltransferase ZDHHC8

Source gene: ZDHHC8

Class: DEG_SPOP_SBC_1

Location: 639:643

E3 ligase: SPOP

DEGRON score: 0.9525

ASA_SCORE: 84.46

COIL: 0.8822

CONS_SCORE: 0.2625

DSS_SCORE: 0.6573

HELIX: 0.0746

FCONS_SCORE: 1.0592

RIG_SCORE: 0.572

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S642L	TCGA-ER-A199	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.R640W	DO227855	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7523
p.S645F	TCGA-Q9-A6FW	ESCA	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7222
p.S645Y	SIDM00499	Prostate Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.7222
p.S645Y	ACH-000956	Prostate Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.7222
p.S642P	TCGA-EO-A3B0	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6752
p.S642P	DO219773	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.P641S	DO10582	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.P641S	DO47368	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.R640Q	TCGA-HU-A4GQ	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R640Q	DO47767	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6218
p.G644S	DO10880	GBM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R638W	DO41331	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R638W	RKO	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.L646Q	DO229275	THCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.P634L	DO52034	HNSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P634L	SNU-1040	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P634S	DO37444	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.A648V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.A648V	ACH-002256	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1944
p.A648V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P652S	DO222521	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 22 of 22 entries

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Drug responses associated with ZDHHC8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...

Showing 1 to 23 of 23 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with ZDHHC8 mutations

All proteins holding degron of PRTSS