DegronMD

Uniprot ID: Q6RVD6

Source protein: Spermatogenesis-associated protein 8

Source gene: SPATA8

Class: DEG_SPOP_SBC_1

Location: 29:33

E3 ligase: SPOP

DEGRON score: 0.8857

ASA_SCORE: 77.34

COIL: 0.8728

CONS_SCORE: 1

DSS_SCORE: 0.3476

HELIX: 0.0934

FCONS_SCORE: 1

RIG_SCORE: 0.6841

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C42F	TCGA-05-5420	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0833
p.C42F	DO26005	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.S32L	TCGA-33-6738	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S32L	TCGA-B5-A3FA	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S32L	TCGA-BF-A3DL	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S32L	TCGA-ZF-A9R7	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.P43L	TCGA-44-8119	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P43L	TCGA-BF-A9VF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P43L	DO24399	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P43L	DO219458	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.S33L	TCGA-55-8085	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	TCGA-5M-AATE	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	TCGA-EE-A2MS	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	DO223704	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	DO45326	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	DO227676	PBCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S33L	DO37567	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7667
p.S22Y	TCGA-66-2759	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.S22Y	DO27326	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.M40L	TCGA-AG-4001	READ	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.A20V	TCGA-AX-A1CE	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0833
p.A20V	DO42280	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.P43S	TCGA-B5-A0K7	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P43T	TCGA-BF-A9VF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P43T	DO219458	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.F36L	TCGA-BR-8680	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.F36L	DO47769	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.P29H	TCGA-D3-A2JL	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7694
p.P29H	DO47278	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7694
p.A39T	TCGA-D3-A8GC	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1667
p.A39T	DO50281	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.R34Q	TCGA-D3-A8GI	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R34Q	DO50284	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.A20D	TCGA-EO-A22U	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0833
p.A20D	DO43755	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.R30I	TCGA-EY-A1GO	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6991
p.R30I	DO41392	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6991
p.Q24H	TCGA-G7-6797	KIRP	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1944
p.Q24H	DO20917	KIRP	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.V20A	DO222874	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.V20A	DO36578	READ	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.V20E	DO234390	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.S37P	DO234413	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2222
p.I19M	DO228429	MALY	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P34S	DO220906	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.P34S	DO47480	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.G19D	DO222595	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.G24R	DO222743	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.L28P	DO32596	OV	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.D33N	DO229459	SKCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6932
p.D33N	DO37823	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6932
p.D33N	DO51273	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6932
p.G24E	DO37406	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.G24E	DO51254	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.G19S	DO50141	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.E26K	DO41752	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.G41V	ACH-000278	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1111
p.G36S	ACH-000408	Esophageal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.25
p.G36S	TE-5	oesophagus	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.25
p.K40E	ACH-000937	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1389
p.K40E	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.D33E	ACH-001669	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	0.6758
p.D33E	ACH-002238	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	0.6758
p.D33E	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.6758
p.E38K	ACH-002312	Gallbladder Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1944
p.E38K	TGBC24TKB	biliary_tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with SPATA8 mutations

All proteins holding degron of PRTSS