DegronMD - Q14162(SCARF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D521Y	TCGA-24-2288	OV	TCGA	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.1944
p.I576M	TCGA-77-8146	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.3056
p.A575V	TCGA-A5-A0G2	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.D526N	TCGA-AP-A0LM	UCEC	TCGA	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.5821
p.D526N	TCGA-D3-A51R	SKCM	TCGA	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.5821
p.D526N	DO47480	SKCM	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.5821
p.D526N	DO43306	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.5821
p.A585V	TCGA-D3-A2JH	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.A585V	DO47263	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.R584W	TCGA-EE-A20C	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.R584W	TCGA-IB-7651	PAAD	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.R584W	DO46657	PAAD	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.R584W	DO47665	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.R587W	TCGA-FP-A4BE	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.R587W	DO48016	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.R584Q	TCGA-G4-6586	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.R584Q	DO9698	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.G516S	TCGA-MX-A5UJ	STAD	TCGA	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.0556
p.G516S	DO48547	STAD	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.0556
p.D521N	TCGA-P4-AAVL	KIRP	TCGA	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.1944
p.R578C	DO225349	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.719
p.P567L	DO50090	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.0556
p.F523S	DO28105	OV	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.25
p.P538L	DO220239	SARC	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.1389
p.W534C	DO229272	THCA	ICGC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.25
p.S524T	SIDM01095	Rhabdomyosarcoma	GDSC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.2778
p.S524T	ACH-000833	Sarcoma	CCLE	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.2778
p.S524T	SJRH30	soft tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.2778
p.P577L	SIDM00837	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7582
p.P577L	ACH-000958	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7582
p.P577L	SW48	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7582
p.P541L	ACH-001367	Neuroblastoma	CCLE	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation rewiring degron network	0.0556
p.P530H	LS-411N	large intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.7694
p.K531R	SNU-1040	large intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.7237
p.K531R	PF-382	haematopoietic and lymphoid tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.7237
p.R528Q	SNU-1040	large intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	526:531	Mutation altering degron motif	0.7329

Kaplan plot for SCARF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCARF1

UniProt ID: Q14162

Entrez ID: 8578

Protein name: Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCARF1 in