DegronMD

Uniprot ID: Q14162

Source protein: Scavenger receptor class F member 1

Source gene: SCARF1

Class: DEG_Kelch_Keap1_1

Location: 526:531

E3 ligase: KEAP1

DEGRON score: 0.606

ASA_SCORE: 81.8

COIL: 0.8605

CONS_SCORE: 0.4316

DSS_SCORE: 0.6808

HELIX: 0.0895

FCONS_SCORE: 0.9419

RIG_SCORE: 0.5937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D521Y	TCGA-24-2288	OV	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.1944
p.D526N	TCGA-AP-A0LM	UCEC	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.5821
p.D526N	TCGA-D3-A51R	SKCM	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.5821
p.D526N	DO47480	SKCM	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.5821
p.D526N	DO43306	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.5821
p.G516S	TCGA-MX-A5UJ	STAD	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.0556
p.G516S	DO48547	STAD	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.0556
p.D521N	TCGA-P4-AAVL	KIRP	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.1944
p.F523S	DO28105	OV	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.25
p.P538L	DO220239	SARC	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.1389
p.W534C	DO229272	THCA	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.25
p.S524T	SIDM01095	Rhabdomyosarcoma	GDSC	DPESGE	DEG_Kelch_Keap1_1	0.2778
p.S524T	ACH-000833	Sarcoma	CCLE	DPESGE	DEG_Kelch_Keap1_1	0.2778
p.S524T	SJRH30	soft_tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.2778
p.P541L	ACH-001367	Neuroblastoma	CCLE	DPESGE	DEG_Kelch_Keap1_1	0.0556
p.P530H	LS-411N	large_intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.7694
p.K531R	SNU-1040	large_intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.7237
p.K531R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.7237
p.R528Q	SNU-1040	large_intestine	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14162	Scavenger receptor class F member 1	DEG_Kelch_Keap1_1	526:531	DPESGE	KEAP1	0.606	More...
Q76MJ5	Serine/threonine-protein kinase/endoribonuclease IRE2	DEG_Kelch_Keap1_1	137:142	DPESGE	KEAP1	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons