DegronMD

Uniprot ID: Q76MJ5

Source protein: Serine/threonine-protein kinase/endoribonuclease IRE2

Source gene: ERN2

Class: DEG_Kelch_Keap1_1

Location: 137:142

E3 ligase: KEAP1

DEGRON score: 0.9863

ASA_SCORE: 59.2

COIL: 0.8863

CONS_SCORE: 0.4774

DSS_SCORE: 0.4405

HELIX: 0.0227

FCONS_SCORE: 1.2806

RIG_SCORE: 0.744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A134T	TCGA-19-5956	GBM	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.25
p.G136D	TCGA-AJ-A3BH	UCEC	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.3056
p.G136D	DO41638	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.3056
p.G148E	TCGA-DX-AB2E	SARC	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.1667
p.G148E	DO220073	SARC	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.1667
p.G148E	DO229462	SKCA	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.1667
p.G142R	TCGA-MN-A4N1	LUAD	TCGA	DPESGE	DEG_Kelch_Keap1_1	0.7568
p.G142R	DO45328	LUAD	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.7568
p.D131N	DO233119	GACA	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.1667
p.V136A	DO48172	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	0.3056
p.R128W	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DPESGE	DEG_Kelch_Keap1_1	0.0833
p.R128W	ACH-000922	Leukemia	CCLE	DPESGE	DEG_Kelch_Keap1_1	0.0833
p.R128W	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	0.0833
p.T148I	ACH-000968	Skin Cancer	CCLE	DPESGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14162	Scavenger receptor class F member 1	DEG_Kelch_Keap1_1	526:531	DPESGE	KEAP1	0.606	More...
Q76MJ5	Serine/threonine-protein kinase/endoribonuclease IRE2	DEG_Kelch_Keap1_1	137:142	DPESGE	KEAP1	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons