DegronMD - Q76MJ5(ERN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q331K	TCGA-17-Z062	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.3056
p.A134T	TCGA-19-5956	GBM	TCGA	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.25
p.D320E	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation altering degron motif	0.6758
p.D320N	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation altering degron motif	0.6932
p.R319P	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation altering degron motif	0.7512
p.R312G	TCGA-A3-A6NN	KIRC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.1944
p.G136D	TCGA-AJ-A3BH	UCEC	TCGA	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.3056
p.G136D	DO41638	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.3056
p.R312Q	TCGA-AU-6004	COAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.1944
p.F325L	TCGA-B5-A0JY	UCEC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation altering degron motif	0.6981
p.R307S	TCGA-D3-A2JC	SKCM	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.0556
p.A315S	TCGA-DF-A2KU	UCEC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.2778
p.G148E	TCGA-DX-AB2E	SARC	TCGA	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.1667
p.G148E	DO220073	SARC	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.1667
p.G148E	DO229462	SKCA	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.1667
p.G142R	TCGA-MN-A4N1	LUAD	TCGA	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation altering degron motif	0.7568
p.G142R	DO45328	LUAD	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation altering degron motif	0.7568
p.T335M	DO222973	BTCA	ICGC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.1944
p.T335M	DO227709	COCA	ICGC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.1944
p.D131N	DO233119	GACA	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.1667
p.V136A	DO48172	UCEC	ICGC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.3056
p.R128W	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.0833
p.R128W	ACH-000922	Leukemia	CCLE	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.0833
p.R128W	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.0833
p.V308M	SIDM01387	Small Cell Lung Carcinoma	GDSC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.0833
p.V308M	ACH-000921	Lung Cancer	CCLE	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	317:330	Mutation rewiring degron network	0.0833
p.T148I	ACH-000968	Skin Cancer	CCLE	DPESGE	DEG_Kelch_Keap1_1	137:142	Mutation rewiring degron network	0.1667

Kaplan plot for ERN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERN2

UniProt ID: Q76MJ5

Entrez ID: 10595

Protein name: Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERN2 in