DegronMD

Uniprot ID: Q76MJ5

Source protein: Serine/threonine-protein kinase/endoribonuclease IRE2

Source gene: ERN2

Class: DEG_ODPH_VHL_1

Location: 317:330

E3 ligase: VHL

DEGRON score: 0.946

ASA_SCORE: 64.2143

COIL: 0.7929

CONS_SCORE: 0.2887

DSS_SCORE: 0.5361

HELIX: 0.0715

FCONS_SCORE: 0.9607

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q331K	TCGA-17-Z062	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.3056
p.D320E	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.6758
p.D320N	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.6932
p.R319P	TCGA-55-7995	LUAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.7512
p.R312G	TCGA-A3-A6NN	KIRC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.1944
p.R312Q	TCGA-AU-6004	COAD	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.1944
p.F325L	TCGA-B5-A0JY	UCEC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.6981
p.R307S	TCGA-D3-A2JC	SKCM	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.0556
p.A315S	TCGA-DF-A2KU	UCEC	TCGA	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.2778
p.T335M	DO222973	BTCA	ICGC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.1944
p.T335M	DO227709	COCA	ICGC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.1944
p.V308M	SIDM01387	Small Cell Lung Carcinoma	GDSC	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.0833
p.V308M	ACH-000921	Lung Cancer	CCLE	LAPADGPTTDEVTL	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76MJ5	Serine/threonine-protein kinase/endoribonuclease IRE2	DEG_ODPH_VHL_1	317:330	LAPADGPTTDEVTL	VHL	0.946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons