DegronMD

Uniprot ID: Q14162

Source protein: Scavenger receptor class F member 1

Source gene: SCARF1

Class: DEG_SPOP_SBC_1

Location: 577:581

E3 ligase: SPOP

DEGRON score: 0.8725

ASA_SCORE: 60.6

COIL: 0.7064

CONS_SCORE: 0.7611

DSS_SCORE: 0.5369

HELIX: 0.1574

FCONS_SCORE: 0.9801

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I576M	TCGA-77-8146	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.A575V	TCGA-A5-A0G2	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.2778
p.A585V	TCGA-D3-A2JH	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.2222
p.A585V	DO47263	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2222
p.R584W	TCGA-EE-A20C	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.R584W	TCGA-IB-7651	PAAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.R584W	DO46657	PAAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.R584W	DO47665	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.R587W	TCGA-FP-A4BE	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1667
p.R587W	DO48016	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.R584Q	TCGA-G4-6586	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.25
p.R584Q	DO9698	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.R578C	DO225349	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.719
p.P567L	DO50090	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P577L	SIDM00837	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.7582
p.P577L	ACH-000958	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.7582
p.P577L	SW48	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with SCARF1 mutations

All proteins holding degron of PRTSS