DegronMD

Uniprot ID: Q12778

Source protein: Forkhead box protein O1

Source gene: FOXO1

Class: DEG_SPOP_SBC_1

Location: 315:319

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 69.76

COIL: 0.9036

CONS_SCORE: 0.5377

DSS_SCORE: 0.5021

HELIX: 0.0464

FCONS_SCORE: 1.1558

RIG_SCORE: 0.671

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W310L	TCGA-05-4427	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1944
p.W310L	DO23666	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.S329L	TCGA-94-7943	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.5
p.S329L	DO26475	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.5
p.R316Q	TCGA-AN-A046	BRCA	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R316Q	TCGA-EO-A22R	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R316Q	DO1285	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R316Q	DO42713	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R316Q	SIDM01943	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.6218
p.R314H	TCGA-AX-A06F	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	TCGA-B5-A3FC	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	TCGA-F5-6814	READ	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	TCGA-XK-AAIW	PRAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	DO51407	PRAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	DO36556	READ	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	DO41752	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314H	DO41871	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.F313V	TCGA-B5-A3FA	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.2778
p.F313V	DO52402	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.G326R	TCGA-CJ-4913	KIRC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.G326R	DO20377	KIRC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.R314C	TCGA-D1-A17Q	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314C	TCGA-D3-A51G	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314C	TCGA-F4-6570	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314C	DO10443	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314C	DO47700	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.R314C	DO41903	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.G326V	TCGA-EE-A181	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1389
p.G326V	DO37444	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.T323A	TCGA-FS-A1ZZ	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6667
p.T323A	DO37412	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6667
p.N309S	DO48424	BLCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.N309D	SIDM00537	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.N309D	ACH-000982	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1667
p.N309D	ACH-001345	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1667
p.N309D	GP5d	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.S325T	ACH-001737	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with FOXO1 mutations

All proteins holding degron of PRTSS