DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.7313

ASA_SCORE: 98.44

COIL: 0.923

CONS_SCORE: 0.5228

DSS_SCORE: 0.8243

HELIX: 0.021

FCONS_SCORE: 1.0248

RIG_SCORE: 0.6035

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R61G	TCGA-34-5234	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P64H	TCGA-43-5670	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.2778
p.P71L	TCGA-85-8287	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.3056
p.T66S	TCGA-D5-5539	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7116
p.P70L	TCGA-EB-A5UN	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.7582
p.R78I	TCGA-EO-A22X	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	0.1111
p.P68S	TCGA-VQ-AA6D	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6752
p.S67C	DO51943	BLCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7541
p.G63R	DO219917	DLBC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.Q75P	DO234346	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1944
p.P56Q	DO229022	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P57R	DO44668	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.P64S	DO52303	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.P64S	DO23130	LINC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.2778
p.S68F	DO52241	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7982
p.S68F	DO38105	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7982
p.S68F	Sarc9371	bone	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.7982
p.S66P	DO23104	LINC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.G63W	DO231719	LINC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.A80S	DO230929	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.A80S	DO224572	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.S65F	DO220879	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.P78L	DO229149	NKTL	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.S69P	DO229259	THCA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.S66Y	DO219771	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.712
p.S71Y	DO43202	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.P59A	ACH-000188	Head and Neck Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1389
p.P59A	SCC-25	upper_aerodigestive_tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.T80K	ACH-000236	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.0556
p.T80K	SW1417	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P58L	ACH-000510	Lung Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.1111
p.P58L	NCI-H1299	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.G79V	ACH-000790	Lung Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.0833
p.G79V	SHP-77	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.0833
p.R67I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.6991
p.P69L	NCI-H1299	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.7582
p.S78F	Sarc9371	bone	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.G59V	SHP-77	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1389
p.T60K	SW1417	large_intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1667
p.P70A	SCC-25	upper_aerodigestive_tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.7503
p.T58K	5637	urinary_tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.L62M	ACN	autonomic_ganglia	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with RUNX1T1 mutations

All proteins holding degron of PRTSS