DegronMD - O95196(CSPG5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E481K	TCGA-AX-A06H	UCEC	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.E481K	TCGA-K4-AAQO	BLCA	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.E481K	DO219030	BLCA	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.E481K	DO43530	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.D261N	TCGA-BR-6452	STAD	TCGA	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation altering degron motif	0.5821
p.D261N	DO38404	STAD	ICGC	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation altering degron motif	0.5821
p.R495S	TCGA-D3-A2J6	SKCM	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.6316
p.R495S	TCGA-D3-A2J6	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.6316
p.R495S	DO37901	SKCM	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.6316
p.R495S	DO37901	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.6316
p.T496I	TCGA-FP-7998	STAD	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.5966
p.T496I	TCGA-FP-7998	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.7078
p.T496I	DO38190	STAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.5966
p.T496I	DO38190	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.7078
p.S497Y	TCGA-H4-A2HQ	BLCA	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.712
p.S497Y	TCGA-H4-A2HQ	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.712
p.S497Y	DO522	BLCA	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.712
p.S497Y	DO522	BLCA	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.712
p.R495C	DO234350	ESAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.719
p.R495C	DO234350	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.719
p.R495C	DO51082	PRAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.719
p.R495C	DO51082	PRAD	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.719
p.S490N	DO24940	LUAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.7069
p.P489S	DO222662	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation substituting flanking lysine	0.3056
p.D264H	DO46528	OV	ICGC	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation rewiring degron network	0.2778
p.T258A	DO229211	THCA	ICGC	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation altering degron motif	0.6028
p.K494N	DO40884	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.6918
p.K494N	DO40884	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.6918
p.A505V	DO41199	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.1111
p.A505V	DO41199	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.1389
p.H506D	SIDM00381	Cervical Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.H506D	SIDM00381	Cervical Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.1111
p.H506D	SKG-IIIa	cervix	COSMIC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.0833
p.H506D	SKG-IIIa	cervix	COSMIC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.1111
p.R495H	SIDM01770	Gastric Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation altering degron motif	0.7133
p.R495H	SIDM01770	Gastric Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	494:498	Mutation altering degron motif	0.7133
p.S483Y	SIDM00500	Colorectal Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.1389
p.S483Y	ACH-000959	Colon/Colorectal Cancer	CCLE	LCNTPRTS	DEG_SCF_FBW7_1	490:497	Mutation rewiring degron network	0.1389
p.D256N	ACH-001973	Metastasis	CCLE	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation rewiring degron network	0.3056
p.E253D	OVK-18	ovary	COSMIC	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation rewiring degron network	0.2222
p.R260S	H3255	lung	COSMIC	FTPFDE	LIG_APCC_ABBA_1	257:262	Mutation altering degron motif	0.7427

Kaplan plot for CSPG5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSPG5

UniProt ID: O95196

Entrez ID: 10675

Protein name: Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSPG5 in