DegronMD

Uniprot ID: O95196

Source protein: Chondroitin sulfate proteoglycan 5

Source gene: CSPG5

Class: DEG_SCF_FBW7_1

Location: 490:497

E3 ligase: FBXW7

DEGRON score: 0.9745

ASA_SCORE: 82.6

COIL: 0.9143

CONS_SCORE: 0.3996

DSS_SCORE: 0.5261

HELIX: 0.0478

FCONS_SCORE: 0.6722

RIG_SCORE: 0.6724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E481K	TCGA-AX-A06H	UCEC	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.E481K	TCGA-K4-AAQO	BLCA	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.E481K	DO219030	BLCA	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.E481K	DO43530	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.R495S	TCGA-D3-A2J6	SKCM	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	0.6316
p.R495S	DO37901	SKCM	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.6316
p.T496I	TCGA-FP-7998	STAD	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	0.5966
p.T496I	DO38190	STAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.5966
p.S497Y	TCGA-H4-A2HQ	BLCA	TCGA	LCNTPRTS	DEG_SCF_FBW7_1	0.712
p.S497Y	DO522	BLCA	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.712
p.R495C	DO234350	ESAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.719
p.R495C	DO51082	PRAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.719
p.S490N	DO24940	LUAD	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.7069
p.K494N	DO40884	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.6918
p.A505V	DO41199	UCEC	ICGC	LCNTPRTS	DEG_SCF_FBW7_1	0.1111
p.H506D	SIDM00381	Cervical Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.H506D	SKG-IIIa	cervix	COSMIC	LCNTPRTS	DEG_SCF_FBW7_1	0.0833
p.R495H	SIDM01770	Gastric Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	0.7133
p.S483Y	SIDM00500	Colorectal Carcinoma	GDSC	LCNTPRTS	DEG_SCF_FBW7_1	0.1389
p.S483Y	ACH-000959	Colon/Colorectal Cancer	CCLE	LCNTPRTS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95196	Chondroitin sulfate proteoglycan 5	DEG_SCF_FBW7_1	490:497	LCNTPRTS	FBXW7	0.9745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons