DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FTPFDE
Uniprot ID:
O95196
Source protein:
Chondroitin sulfate proteoglycan 5
Source gene:
CSPG5
Class:
LIG_APCC_ABBA_1
Location:
257:262
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9237
ASA_SCORE:
64.8833
COIL:
0.8257
CONS_SCORE:
0.5253
DSS_SCORE:
0.4887
HELIX:
0.0782
FCONS_SCORE:
1.0973
RIG_SCORE:
0.7646
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D261N
TCGA-BR-6452
STAD
TCGA
FTPFDE
LIG_APCC_ABBA_1
0.5821
p.D261N
DO38404
STAD
ICGC
FTPFDE
LIG_APCC_ABBA_1
0.5821
p.D264H
DO46528
OV
ICGC
FTPFDE
LIG_APCC_ABBA_1
0.2778
p.T258A
DO229211
THCA
ICGC
FTPFDE
LIG_APCC_ABBA_1
0.6028
p.D256N
ACH-001973
Metastasis
CCLE
FTPFDE
LIG_APCC_ABBA_1
0.3056
p.E253D
OVK-18
ovary
COSMIC
FTPFDE
LIG_APCC_ABBA_1
0.2222
p.R260S
H3255
lung
COSMIC
FTPFDE
LIG_APCC_ABBA_1
0.7427
Drug responses associated with CSPG5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FTPFDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95196
Chondroitin sulfate proteoglycan 5
LIG_APCC_ABBA_1
257:262
FTPFDE
APC,CDC20,FZR1
0.9237
More...