DegronMD

Uniprot ID: O95196

Source protein: Chondroitin sulfate proteoglycan 5

Source gene: CSPG5

Class: LIG_APCC_ABBA_1

Location: 257:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9237

ASA_SCORE: 64.8833

COIL: 0.8257

CONS_SCORE: 0.5253

DSS_SCORE: 0.4887

HELIX: 0.0782

FCONS_SCORE: 1.0973

RIG_SCORE: 0.7646

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R260S	H3255	lung	COSMIC	FTPFDE	LIG_APCC_ABBA_1	0.7427
p.T258A	DO229211	THCA	ICGC	FTPFDE	LIG_APCC_ABBA_1	0.6028
p.D261N	TCGA-BR-6452	STAD	TCGA	FTPFDE	LIG_APCC_ABBA_1	0.5821
p.D261N	DO38404	STAD	ICGC	FTPFDE	LIG_APCC_ABBA_1	0.5821
p.D256N	ACH-001973	Metastasis	CCLE	FTPFDE	LIG_APCC_ABBA_1	0.3056
p.D264H	DO46528	OV	ICGC	FTPFDE	LIG_APCC_ABBA_1	0.2778
p.E253D	OVK-18	ovary	COSMIC	FTPFDE	LIG_APCC_ABBA_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95196	Chondroitin sulfate proteoglycan 5	LIG_APCC_ABBA_1	257:262	FTPFDE	APC,CDC20,FZR1	0.9237	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons