DegronMD - Q76KD6(SPATC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P365T	TCGA-18-3406	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0556
p.P365T	DO26438	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0556
p.P198A	TCGA-94-8491	LUSC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.25
p.P198A	DO219174	LUSC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.25
p.P382S	TCGA-BR-4256	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1111
p.P382S	DO38743	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1111
p.L183M	TCGA-D5-6929	COAD	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.3056
p.L183M	DO7870	COAD	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.3056
p.V193D	TCGA-DI-A1BU	UCEC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.7785
p.V193D	DO42023	UCEC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.7785
p.S402Y	TCGA-DK-A2I1	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation blocking phosphorylation signal	0.5556
p.S402Y	DO444	BLCA	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation blocking phosphorylation signal	0.5556
p.A358T	TCGA-EI-6917	READ	TCGA	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.25
p.A358T	DO36881	READ	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.25
p.Q179H	TCGA-EO-A22R	UCEC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.1944
p.Q179H	DO23518	LIRI	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.1944
p.Q179H	DO42713	UCEC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.1944
p.T350K	TCGA-ER-A19P	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.3056
p.T350K	DO47623	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.3056
p.P396T	TCGA-FS-A1ZG	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2778
p.P396T	DO37523	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2778
p.S194F	TCGA-FS-A1ZQ	SKCM	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6871
p.S194F	DO37442	SKCM	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6871
p.P186H	TCGA-HF-A5NB	STAD	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.7694
p.P186H	DO50127	STAD	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.7694
p.P364T	TCGA-HU-A4H4	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0833
p.P364T	DO47721	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0833
p.R391H	TCGA-S9-A7IS	LGG	TCGA	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7133
p.R391H	DO48606	LGG	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7133
p.P362T	DO222404	BTCA	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1389
p.R391C	DO222443	BTCA	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.719
p.A397S	DO228948	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.25
p.P182S	DO50832	LIRI	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation rewiring degron network	0.2778
p.A346D	DO231031	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.S352T	DO46606	OV	ICGC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.6005
p.V187M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6097
p.V187M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6097
p.V187M	ACH-000995	Leukemia	CCLE	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6097
p.V187M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6097
p.H363R	SIDM00099	Mesothelioma	GDSC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.H363R	ACH-002128	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.H363R	H2722	pleura	COSMIC	PSSTT	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.A185V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6936
p.A185V	ACH-002256	Leukemia	CCLE	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6936
p.A185V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	184:195	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATC1

UniProt ID: Q76KD6

Entrez ID: 375686

Protein name: Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATC1 in