DegronMD

Uniprot ID: Q76KD6

Source protein: Speriolin

Source gene: SPATC1

Class: DEG_ODPH_VHL_1

Location: 184:195

E3 ligase: VHL

DEGRON score: 0.8161

ASA_SCORE: 81.5667

COIL: 0.9238

CONS_SCORE: 0.4879

DSS_SCORE: 0.2133

HELIX: 0.0241

FCONS_SCORE: 0.8398

RIG_SCORE: 0.7716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P198A	TCGA-94-8491	LUSC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.25
p.P198A	DO219174	LUSC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.25
p.L183M	TCGA-D5-6929	COAD	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.3056
p.L183M	DO7870	COAD	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.3056
p.V193D	TCGA-DI-A1BU	UCEC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.7785
p.V193D	DO42023	UCEC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.7785
p.Q179H	TCGA-EO-A22R	UCEC	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.1944
p.Q179H	DO23518	LIRI	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.1944
p.Q179H	DO42713	UCEC	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.1944
p.S194F	TCGA-FS-A1ZQ	SKCM	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6871
p.S194F	DO37442	SKCM	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6871
p.P186H	TCGA-HF-A5NB	STAD	TCGA	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.7694
p.P186H	DO50127	STAD	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.7694
p.P182S	DO50832	LIRI	ICGC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.2778
p.V187M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6097
p.V187M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6097
p.V187M	ACH-000995	Leukemia	CCLE	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6097
p.V187M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6097
p.A185V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6936
p.A185V	ACH-002256	Leukemia	CCLE	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6936
p.A185V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IAPVMGTVAVSL	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76KD6	Speriolin	DEG_ODPH_VHL_1	184:195	IAPVMGTVAVSL	VHL	0.8161	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons