DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SPOP_SBC_1

Location: 2346:2350

E3 ligase: SPOP

DEGRON score: 0.9898

ASA_SCORE: 105.06

COIL: 0.9702

CONS_SCORE: 0.4498

DSS_SCORE: 0.7774

HELIX: 0.0116

FCONS_SCORE: 1.056

RIG_SCORE: 0.5725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2360S	TCGA-CK-5914	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	0.0556
p.G2360S	DO9658	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.0556
p.P2346S	TCGA-EE-A29E	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	0.6752
p.P2346S	DO37831	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	0.6752
p.P2338H	DO8898	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.S2350F	DO234253	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	0.7982
p.K2357T	DO47092	RECA	ICGC	PRTSS	DEG_SPOP_SBC_1	0.25
p.S2358P	SIDM01964	Esophageal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.1111
p.L2342F	SIDM00564	Ovarian Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.2222
p.L2342F	ACH-000527	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.2222
p.L2342F	OVISE	ovary	COSMIC	PRTSS	DEG_SPOP_SBC_1	0.2222
p.L2345I	SIDM00008	Ovarian Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	0.3056
p.L2345I	ACH-000796	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	416:420	PRTSS	SPOP	0.8831	More...
O95196	Chondroitin sulfate proteoglycan 5	DEG_SPOP_SBC_1	494:498	PRTSS	SPOP	0.9445	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2346:2350	PRTSS	SPOP	0.9898	More...
Q03111	Protein ENL	DEG_SPOP_SBC_1	316:320	PRTSS	SPOP	0.7245	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	66:70	PRTSS	SPOP	0.7313	More...
Q12778	Forkhead box protein O1	DEG_SPOP_SBC_1	315:319	PRTSS	SPOP	0.9972	More...
Q14162	Scavenger receptor class F member 1	DEG_SPOP_SBC_1	577:581	PRTSS	SPOP	0.8725	More...
Q6GPH4	XIAP-associated factor 1	DEG_SPOP_SBC_1	249:253	PRTSS	SPOP	0.8792	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1161:1165	PRTSS	SPOP	0.8865	More...
Q6RVD6	Spermatogenesis-associated protein 8	DEG_SPOP_SBC_1	29:33	PRTSS	SPOP	0.8857	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1462:1466	PRTSS	SPOP	0.9516	More...
Q96QH2	PML-RARA-regulated adapter molecule 1	DEG_SPOP_SBC_1	330:334	PRTSS	SPOP	0.9947	More...
Q9BRG2	SH2 domain-containing protein 3A	DEG_SPOP_SBC_1	176:180	PRTSS	SPOP	0.9677	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	581:585	PRTSS	SPOP	0.9948	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	354:358	PRTSS	SPOP	0.9618	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	778:782	PRTSS	SPOP	0.9406	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	919:923	PRTSS	SPOP	0.9535	More...
Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	DEG_SPOP_SBC_1	346:350	PRTSS	SPOP	0.9945	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SPOP_SBC_1	461:465	PRTSS	SPOP	0.8829	More...
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SPOP_SBC_1	639:643	PRTSS	SPOP	0.9525	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	610:614	PRTSS	SPOP	0.9746	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	390:394	PRTSS	SPOP	0.8987	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	124:128	PRTSS	SPOP	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTSS

Degron related mutations and impact score

Drug responses associated with APC mutations

All proteins holding degron of PRTSS