DegronMD - Q6RVD6(SPATA8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C42F	TCGA-05-5420	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.C42F	DO26005	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.S32L	TCGA-33-6738	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S32L	TCGA-B5-A3FA	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S32L	TCGA-BF-A3DL	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S32L	TCGA-ZF-A9R7	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.P43L	TCGA-44-8119	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P43L	TCGA-BF-A9VF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P43L	DO24399	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P43L	DO219458	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.S33L	TCGA-55-8085	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	TCGA-5M-AATE	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	TCGA-EE-A2MS	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	DO223704	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	DO45326	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	DO227676	PBCA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S33L	DO37567	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7667
p.S22Y	TCGA-66-2759	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.S22Y	DO27326	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.M40L	TCGA-AG-4001	READ	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.A20V	TCGA-AX-A1CE	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.A20V	DO42280	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.P43S	TCGA-B5-A0K7	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P43T	TCGA-BF-A9VF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P43T	DO219458	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.F36L	TCGA-BR-8680	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.F36L	DO47769	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.P29H	TCGA-D3-A2JL	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7694
p.P29H	DO47278	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7694
p.A39T	TCGA-D3-A8GC	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.A39T	DO50281	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.R34Q	TCGA-D3-A8GI	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.R34Q	DO50284	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.A20D	TCGA-EO-A22U	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.A20D	DO43755	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.R30I	TCGA-EY-A1GO	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6991
p.R30I	DO41392	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6991
p.Q24H	TCGA-G7-6797	KIRP	TCGA	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.Q24H	DO20917	KIRP	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.V20A	DO222874	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.V20A	DO36578	READ	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.V20E	DO234390	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.S37P	DO234413	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2222
p.I19M	DO228429	MALY	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.P34S	DO220906	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.P34S	DO47480	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.G19D	DO222595	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.G24R	DO222743	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.L28P	DO32596	OV	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.D33N	DO229459	SKCA	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6932
p.D33N	DO37823	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6932
p.D33N	DO51273	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6932
p.G24E	DO37406	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.G24E	DO51254	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.G19S	DO50141	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.E26K	DO41752	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.G41V	ACH-000278	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1111
p.G36S	ACH-000408	Esophageal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.G36S	TE-5	oesophagus	COSMIC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.K40E	ACH-000937	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.K40E	PF-382	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.D33E	ACH-001669	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6758
p.D33E	ACH-002238	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6758
p.D33E	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6758
p.E38K	ACH-002312	Gallbladder Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.E38K	TGBC24TKB	biliary tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA8

UniProt ID: Q6RVD6

Entrez ID:

Protein name: Spermatogenesis-associated protein 8 (Spermatogenesis-related protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA8 in