DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRTSS
Uniprot ID:
Q92538
Source protein:
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Source gene:
GBF1
Class:
DEG_SPOP_SBC_1
Location:
1462:1466
E3 ligase:
SPOP
DEGRON score:
0.9516
ASA_SCORE:
95.56
COIL:
0.8712
CONS_SCORE:
0.2376
DSS_SCORE:
0.8126
HELIX:
0.1044
FCONS_SCORE:
1.079
RIG_SCORE:
0.5921
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1460C
TCGA-A5-A0G2
UCEC
TCGA
PRTSS
DEG_SPOP_SBC_1
0.2778
p.R1460C
DO41235
UCEC
ICGC
PRTSS
DEG_SPOP_SBC_1
0.2778
p.Q1467K
TCGA-AP-A0L8
UCEC
TCGA
PRTSS
DEG_SPOP_SBC_1
0.3056
p.Q1467K
DO42169
UCEC
ICGC
PRTSS
DEG_SPOP_SBC_1
0.3056
p.G1473R
TCGA-B5-A0K6
UCEC
TCGA
PRTSS
DEG_SPOP_SBC_1
0.1389
p.G1473R
TCGA-CV-6941
HNSC
TCGA
PRTSS
DEG_SPOP_SBC_1
0.1389
p.G1473R
DO15919
HNSC
ICGC
PRTSS
DEG_SPOP_SBC_1
0.1389
p.G1473R
DO40808
UCEC
ICGC
PRTSS
DEG_SPOP_SBC_1
0.1389
p.R1471Q
TCGA-CD-A4MG
STAD
TCGA
PRTSS
DEG_SPOP_SBC_1
0.1944
p.R1471Q
DO48009
STAD
ICGC
PRTSS
DEG_SPOP_SBC_1
0.1944
p.R1461Q
DO234293
ESAD
ICGC
PRTSS
DEG_SPOP_SBC_1
0.3056
p.R1460H
DO228756
GACA
ICGC
PRTSS
DEG_SPOP_SBC_1
0.2778
p.R1460L
DO228974
LICA
ICGC
PRTSS
DEG_SPOP_SBC_1
0.2778
p.G1473V
DO228971
LICA
ICGC
PRTSS
DEG_SPOP_SBC_1
0.1389
p.K1452R
DO229211
THCA
ICGC
PRTSS
DEG_SPOP_SBC_1
0.1667
p.R1471W
SIDM00589
Oral Cavity Carcinoma
GDSC
PRTSS
DEG_SPOP_SBC_1
0.1944
p.R1471W
ACH-000778
Head and Neck Cancer
CCLE
PRTSS
DEG_SPOP_SBC_1
0.1944
p.R1471W
HSC-3
upper_aerodigestive_tract
COSMIC
PRTSS
DEG_SPOP_SBC_1
0.1944
p.E1455D
SIDM00769
Non-Small Cell Lung Carcinoma
GDSC
PRTSS
DEG_SPOP_SBC_1
0.1389
p.E1455D
ACH-000733
Lung Cancer
CCLE
PRTSS
DEG_SPOP_SBC_1
0.1389
p.E1455D
NCI-H1838
lung
COSMIC
PRTSS
DEG_SPOP_SBC_1
0.1389
p.L1459F
SIDM00651
Non-Small Cell Lung Carcinoma
GDSC
PRTSS
DEG_SPOP_SBC_1
0.25
p.L1459F
ACH-000980
Lung Cancer
CCLE
PRTSS
DEG_SPOP_SBC_1
0.25
p.L1459F
NCI-H1155
lung
COSMIC
PRTSS
DEG_SPOP_SBC_1
0.25
Drug responses associated with GBF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14526
F-BAR domain only protein 1
DEG_SPOP_SBC_1
416:420
PRTSS
SPOP
0.8831
More...
O95196
Chondroitin sulfate proteoglycan 5
DEG_SPOP_SBC_1
494:498
PRTSS
SPOP
0.9445
More...
P25054
Adenomatous polyposis coli protein
DEG_SPOP_SBC_1
2346:2350
PRTSS
SPOP
0.9898
More...
Q03111
Protein ENL
DEG_SPOP_SBC_1
316:320
PRTSS
SPOP
0.7245
More...
Q06455
Protein CBFA2T1
DEG_SPOP_SBC_1
66:70
PRTSS
SPOP
0.7313
More...
Q12778
Forkhead box protein O1
DEG_SPOP_SBC_1
315:319
PRTSS
SPOP
0.9972
More...
Q14162
Scavenger receptor class F member 1
DEG_SPOP_SBC_1
577:581
PRTSS
SPOP
0.8725
More...
Q6GPH4
XIAP-associated factor 1
DEG_SPOP_SBC_1
249:253
PRTSS
SPOP
0.8792
More...
Q6IQ55
Tau-tubulin kinase 2
DEG_SPOP_SBC_1
1161:1165
PRTSS
SPOP
0.8865
More...
Q6RVD6
Spermatogenesis-associated protein 8
DEG_SPOP_SBC_1
29:33
PRTSS
SPOP
0.8857
More...
Q92538
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
DEG_SPOP_SBC_1
1462:1466
PRTSS
SPOP
0.9516
More...
Q96QH2
PML-RARA-regulated adapter molecule 1
DEG_SPOP_SBC_1
330:334
PRTSS
SPOP
0.9947
More...
Q9BRG2
SH2 domain-containing protein 3A
DEG_SPOP_SBC_1
176:180
PRTSS
SPOP
0.9677
More...
Q9C0B5
Palmitoyltransferase ZDHHC5
DEG_SPOP_SBC_1
581:585
PRTSS
SPOP
0.9948
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_SPOP_SBC_1
354:358
PRTSS
SPOP
0.9618
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_SPOP_SBC_1
778:782
PRTSS
SPOP
0.9406
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_SPOP_SBC_1
919:923
PRTSS
SPOP
0.9535
More...
Q9NYJ8
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
DEG_SPOP_SBC_1
346:350
PRTSS
SPOP
0.9945
More...
Q9UIG0
Tyrosine-protein kinase BAZ1B
DEG_SPOP_SBC_1
461:465
PRTSS
SPOP
0.8829
More...
Q9ULC8
Palmitoyltransferase ZDHHC8
DEG_SPOP_SBC_1
639:643
PRTSS
SPOP
0.9525
More...
Q6ZVL6
UPF0606 protein KIAA1549L
DEG_SPOP_SBC_1
610:614
PRTSS
SPOP
0.9746
More...
Q76KD6
Speriolin
DEG_SPOP_SBC_1
390:394
PRTSS
SPOP
0.8987
More...
Q9BY89
Uncharacterized protein KIAA1671
DEG_SPOP_SBC_1
124:128
PRTSS
SPOP
0.9961
More...