DegronMD - Q6GPH4(XAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S234G	TCGA-17-Z014	LUAD	TCGA	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.S234G	TCGA-17-Z014	LUAD	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.0833
p.R233K	TCGA-AP-A1DV	UCEC	TCGA	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.R233K	TCGA-AP-A1DV	UCEC	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.R233K	DO43186	UCEC	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.R233K	DO43186	UCEC	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.A259T	TCGA-AP-A1DV	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.A259T	DO43186	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.H223Y	TCGA-EE-A182	SKCM	TCGA	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.6118
p.H223Y	TCGA-EE-A182	SKCM	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.6118
p.H223Y	DO37814	SKCM	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.6118
p.H223Y	DO37814	SKCM	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.6118
p.A259S	TCGA-EO-A22R	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.A259S	DO42713	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.A231T	TCGA-QB-A6FS	SKCM	TCGA	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1667
p.A231T	TCGA-QB-A6FS	SKCM	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1667
p.A231T	DO48654	SKCM	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1667
p.A231T	DO48654	SKCM	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1667
p.G256E	DO48194	ESCA	ICGC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.V210I	DO233867	GACA	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.V210I	DO233867	GACA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.0833
p.V210F	DO229026	LICA	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.V210F	DO229026	LICA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.0833
p.V210F	DO229034	LICA	ICGC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.V210F	DO229034	LICA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.0833
p.T251N	SIDM02048	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7055
p.R219I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00544	Neuroblastoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00057	Neuroblastoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00552	Rhabdomyosarcoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00235	Kidney Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00997	Thyroid Gland Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	SIDM00609	Kidney Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000189	Kidney Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000250	Kidney Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000607	Rhabdoid	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000773	Lymphoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000961	Endometrial/Uterine Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-000983	Leukemia	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-001184	Sarcoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-001306	Thyroid Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-001623	Brain Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-001651	Endometrial/Uterine Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R219I	ACH-001716	Neuroblastoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.8102
p.R211C	SIDM00072	Non-Cancerous	GDSC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.R211C	SIDM00072	Non-Cancerous	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.R211C	ACH-000206	Lymphoma	CCLE	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.R211C	ACH-000206	Lymphoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.P212Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.P212Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1389
p.P212Q	ACH-000790	Lung Cancer	CCLE	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.P212Q	ACH-000790	Lung Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1389
p.P212Q	SHP-77	lung	COSMIC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.P212Q	SHP-77	lung	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1389
p.R211P	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.R211P	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.R211P	ACH-000392	Lung Cancer	CCLE	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.R211P	ACH-000392	Lung Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.R211P	Calu-3	lung	COSMIC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.R211P	Calu-3	lung	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1111
p.P249S	SIDM01052	Ovarian Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6752
p.P249S	ACH-000308	Ovarian Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6752
p.P249S	EFO-21	ovary	COSMIC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6752
p.L242R	SIDM01611	Endometrial Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.L242R	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S253Y	ACH-002045	Head and Neck Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.712
p.P230S	EFO-21	ovary	COSMIC	FPLHSE	LIG_APCC_ABBA_1	220:225	Mutation substituting flanking lysine	0.3056
p.P230S	EFO-21	ovary	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XAF1

UniProt ID: Q6GPH4

Entrez ID: 54739

Protein name: XIAP-associated factor 1 (BIRC4-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XAF1 in